Special Issue "Recombination in Viruses"
A special issue of Viruses (ISSN 1999-4915).
Deadline for manuscript submissions: closed (30 April 2011)
Dr. Matteo Negroni
CNRS-UPR 9002, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg, France
Phone: +33 (0)388417006
Fax: +33 (0)388602218
Viruses are in a perpetual arm race with their hosts. Camouflage is a common strategy viruses use to escape to the immune system (either innate or adaptive) of their hosts. This generally translates in a propensity to develop replication strategies that are, at different extents, prone to the insertion of mutations in their genome. Accumulation of mutations is nevertheless limited by the need to maintain viability and its own genetic identity. Keeping the subtle equilibrium between these two contrasting forces is vital for viruses, it often influences their pathogenic potential, and can be at the origin of outbreaks of infection of relevance for public health.
Recombination is an important source of genetic variability in viruses, particularly for viruses possessing an RNA genome. The remarkable power of recombination resides in its ability, in a single infectious cycle, to generate new combinations of mutations. This is important at two regards: one is that recombination does not generate new mutations but reshuffles pre-existing ones, whose compatibility with viral survival has already been established. This is expected to increase the probability of having a viable recombinant progeny. On the other hand, the fact that, in general, several mutations are simultaneously introduced through the recombination process, is expected to favour the opposite outcome: that a high proportion of recombinant products will not be viable. Finally, recombination in concert with natural selection, can be responsible of combining advantageous mutations, as well as removing deleterious ones, by far the most abundant type of mutations found in nature.
For many viruses the generation of recombinant variants has been associated to important moments in the processes of adaptation, gain of pathogenic potential or increased spreading. Here we intend to present several of these cases and to provide an overlook of the implications of recombination for viral evolution from the theoretical standpoint. A life style involving increasing travelling with the result of an extensive intermingling of viruses, the making a reality of intervention strategies (as transgenic crops and gene therapy) often based on the use of viral vectors, all are issues for which an improved understanding of the role of recombination in viral evolution becomes increasingly urgent.
Dr. Matteo Negroni
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed Open Access monthly journal published by MDPI.
- genetic variability
- natural selection
Viruses 2011, 3(8), 1358-1373; doi:10.3390/v3081358
Received: 3 June 2011; in revised form: 12 July 2011 / Accepted: 22 July 2011 / Published: 4 August 2011| Download PDF Full-text (135 KB)
Review: Recombination between Poliovirus and Coxsackie A Viruses of Species C: A Model of Viral Genetic Plasticity and Emergence
Viruses 2011, 3(8), 1460-1484; doi:10.3390/v3081460
Received: 2 June 2011; in revised form: 3 August 2011 / Accepted: 3 August 2011 / Published: 17 August 2011| Download PDF Full-text (2734 KB)
Viruses 2011, 3(9), 1650-1680; doi:10.3390/v3091650
Received: 21 June 2011; in revised form: 18 August 2011 / Accepted: 25 August 2011 / Published: 9 September 2011| Download PDF Full-text (4166 KB)
Viruses 2011, 3(9), 1699-1738; doi:10.3390/v3091699
Received: 8 June 2011; in revised form: 18 August 2011 / Accepted: 5 September 2011 / Published: 13 September 2011| Download PDF Full-text (3832 KB)
Viruses 2011, 3(9), 1777-1799; doi:10.3390/v3091777
Received: 8 August 2011; in revised form: 24 August 2011 / Accepted: 5 September 2011 / Published: 23 September 2011| Download PDF Full-text (1175 KB) |
Viruses 2011, 3(10), 2006-2024; doi:10.3390/v3102006
Received: 20 September 2011 / Accepted: 13 October 2011 / Published: 24 October 2011| Download PDF Full-text (291 KB)
Last update: 28 January 2013