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Homologous Recombination in Negative Sense RNA Viruses
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
* Author to whom correspondence should be addressed.
Received: 3 June 2011; in revised form: 12 July 2011 / Accepted: 22 July 2011 / Published: 4 August 2011
Abstract: Recombination is an important process that influences biological evolution at many different levels. More and more homologous recombination events have been reported among negative sense RNA viruses recently. While sporadic authentic examples indicate that homologous recombination does occur, recombination seems to be generally rare or even absent in most negative sense RNA viruses, and most of the homologous recombination events reported in the literature were likely generated artificially due to lab contamination or inappropriate bioinformatics methods. Homologous recombination in negative sense RNA viruses should be reported with caution in the future, and only after stringent quality control efforts. Moreover, co-infection experiments should be performed to confirm whether recombination can occur.
Keywords: homologous recombination; negative sense RNA viruses; evolution
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MDPI and ACS Style
Han, G.-Z.; Worobey, M. Homologous Recombination in Negative Sense RNA Viruses. Viruses 2011, 3, 1358-1373.
Han G-Z, Worobey M. Homologous Recombination in Negative Sense RNA Viruses. Viruses. 2011; 3(8):1358-1373.
Han, Guan-Zhu; Worobey, Michael. 2011. "Homologous Recombination in Negative Sense RNA Viruses." Viruses 3, no. 8: 1358-1373.