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Viruses 2011, 3(8), 1358-1373; doi:10.3390/v3081358
Review

Homologous Recombination in Negative Sense RNA Viruses

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Received: 3 June 2011 / Revised: 12 July 2011 / Accepted: 22 July 2011 / Published: 4 August 2011
(This article belongs to the Special Issue Recombination in Viruses)
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Abstract

Recombination is an important process that influences biological evolution at many different levels. More and more homologous recombination events have been reported among negative sense RNA viruses recently. While sporadic authentic examples indicate that homologous recombination does occur, recombination seems to be generally rare or even absent in most negative sense RNA viruses, and most of the homologous recombination events reported in the literature were likely generated artificially due to lab contamination or inappropriate bioinformatics methods. Homologous recombination in negative sense RNA viruses should be reported with caution in the future, and only after stringent quality control efforts. Moreover, co-infection experiments should be performed to confirm whether recombination can occur.
Keywords: homologous recombination; negative sense RNA viruses; evolution homologous recombination; negative sense RNA viruses; evolution
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Han, G.-Z.; Worobey, M. Homologous Recombination in Negative Sense RNA Viruses. Viruses 2011, 3, 1358-1373.

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