Viruses 2011, 3(8), 1358-1373; doi:10.3390/v3081358
Review

Homologous Recombination in Negative Sense RNA Viruses

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Received: 3 June 2011; in revised form: 12 July 2011 / Accepted: 22 July 2011 / Published: 4 August 2011
(This article belongs to the Special Issue Recombination in Viruses)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Recombination is an important process that influences biological evolution at many different levels. More and more homologous recombination events have been reported among negative sense RNA viruses recently. While sporadic authentic examples indicate that homologous recombination does occur, recombination seems to be generally rare or even absent in most negative sense RNA viruses, and most of the homologous recombination events reported in the literature were likely generated artificially due to lab contamination or inappropriate bioinformatics methods. Homologous recombination in negative sense RNA viruses should be reported with caution in the future, and only after stringent quality control efforts. Moreover, co-infection experiments should be performed to confirm whether recombination can occur.
Keywords: homologous recombination; negative sense RNA viruses; evolution
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MDPI and ACS Style

Han, G.-Z.; Worobey, M. Homologous Recombination in Negative Sense RNA Viruses. Viruses 2011, 3, 1358-1373.

AMA Style

Han G-Z, Worobey M. Homologous Recombination in Negative Sense RNA Viruses. Viruses. 2011; 3(8):1358-1373.

Chicago/Turabian Style

Han, Guan-Zhu; Worobey, Michael. 2011. "Homologous Recombination in Negative Sense RNA Viruses." Viruses 3, no. 8: 1358-1373.


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