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Viruses 2011, 3(8), 1358-1373; doi:10.3390/v3081358

Homologous Recombination in Negative Sense RNA Viruses

*  and
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
* Author to whom correspondence should be addressed.
Received: 3 June 2011 / Revised: 12 July 2011 / Accepted: 22 July 2011 / Published: 4 August 2011
(This article belongs to the Special Issue Recombination in Viruses)
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Recombination is an important process that influences biological evolution at many different levels. More and more homologous recombination events have been reported among negative sense RNA viruses recently. While sporadic authentic examples indicate that homologous recombination does occur, recombination seems to be generally rare or even absent in most negative sense RNA viruses, and most of the homologous recombination events reported in the literature were likely generated artificially due to lab contamination or inappropriate bioinformatics methods. Homologous recombination in negative sense RNA viruses should be reported with caution in the future, and only after stringent quality control efforts. Moreover, co-infection experiments should be performed to confirm whether recombination can occur.
Keywords: homologous recombination; negative sense RNA viruses; evolution homologous recombination; negative sense RNA viruses; evolution
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Han, G.-Z.; Worobey, M. Homologous Recombination in Negative Sense RNA Viruses. Viruses 2011, 3, 1358-1373.

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