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Viruses 2011, 3(9), 1650-1680; doi:10.3390/v3091650

Mechanisms and Factors that Influence High Frequency Retroviral Recombination

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Received: 21 June 2011 / Revised: 18 August 2011 / Accepted: 25 August 2011 / Published: 9 September 2011
(This article belongs to the Special Issue Recombination in Viruses)
Download PDF [4166 KB, uploaded 9 September 2011]
Abstract: With constantly changing environmental selection pressures, retroviruses rely upon recombination to reassort polymorphisms in their genomes and increase genetic diversity, which improves the chances for the survival of their population. Recombination occurs during DNA synthesis, whereby reverse transcriptase undergoes template switching events between the two copackaged RNAs, resulting in a viral recombinant with portions of the genetic information from each parental RNA. This review summarizes our current understanding of the factors and mechanisms influencing retroviral recombination, fidelity of the recombination process, and evaluates the subsequent viral diversity and fitness of the progeny recombinant. Specifically, the high mutation rates and high recombination frequencies of HIV-1 will be analyzed for their roles in influencing HIV-1 global diversity, as well as HIV-1 diagnosis, drug treatment, and vaccine development.
Keywords: recombination; retrovirus; HIV-1 recombination; retrovirus; HIV-1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Delviks-Frankenberry, K.; Galli, A.; Nikolaitchik, O.; Mens, H.; Pathak, V.K.; Hu, W.-S. Mechanisms and Factors that Influence High Frequency Retroviral Recombination. Viruses 2011, 3, 1650-1680.

AMA Style

Delviks-Frankenberry K, Galli A, Nikolaitchik O, Mens H, Pathak VK, Hu W-S. Mechanisms and Factors that Influence High Frequency Retroviral Recombination. Viruses. 2011; 3(9):1650-1680.

Chicago/Turabian Style

Delviks-Frankenberry, Krista; Galli, Andrea; Nikolaitchik, Olga; Mens, Helene; Pathak, Vinay K.; Hu, Wei-Shau. 2011. "Mechanisms and Factors that Influence High Frequency Retroviral Recombination." Viruses 3, no. 9: 1650-1680.

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