Special Issue "Hepatitis C Pathology"

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A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: closed (30 November 2012)

Special Issue Editor

Guest Editor
Dr. Birke Bartosch
Centre de recherche en cancérologie de Lyon, UMR 5286, UMR_S 1052, Equipe 15, 151 cours Albert Thomas, 69424 Lyon Cedex 03, France
Website: http://cvscience.aviesan.fr/cv/963/birke-bartosch
E-Mail: birke.bartosch@inserm.fr
Phone: +33 472681975
Fax: +33 472681971
Interests: flavivirus; hepatitis C virus; hepatitis B virus; virus-host cell interactions; hepatology; liver physiopathology; antivirals

Special Issue Information

Dear Colleagues,

Worldwide approximately 130 million people are thought to be infected with hepatitis C virus (HCV). HCV frequently induces chronic liver disease and on the long term cirrhosis and hepatocellular carcinoma. The major clinical manifestations of chronic hepatitis C comprise steatosis, insulin resistance and type 2 diabetes. Mounting evidence suggests that HCV reprograms it’s host metabolism and modulates immune responses. These alterations contribute to the establishment of a liver microenvironment that is favorable for persistent viral replication, but that is also characterized by increased levels of oxidative stress, altered cytokine patterns and inflammatory responses that can trigger auto-immunity as well as fibrosis and ultimately hepatocarcinogenesis. Unraveling the interactions between HCV and its host and the consequential effects on the liver microenvironment and disease progression is an important task in the field. Understanding these events will help to improve therapy and patient care.

Investigators are invited to contribute original research articles or reviews that help us to understand the molecular pathology of chronic hepatitis C with a particular focus on disease progression in respect to:

  • metabolic predisposition and HCV infection
  • HCV- induced disturbances of carbohydrate and lipid metabolism
  • HCV- induced alterations of the energy and redox systems
  • HCV-induced alterations of cytokine signaling
  • HCV and autoimmunity

Dr. Birke Bartosch
Guest Editor

Published Papers (12 papers)

Viruses 2013, 5(3), 954-980; doi:10.3390/v5030954
Received: 22 February 2013; in revised form: 15 March 2013 / Accepted: 20 March 2013 / Published: 21 March 2013
Show/Hide Abstract | Cited by 5 | PDF Full-text (1631 KB) | HTML Full-text | XML Full-text

Viruses 2012, 4(12), 3912-3931; doi:10.3390/v4123912
Received: 24 October 2012; in revised form: 3 December 2012 / Accepted: 5 December 2012 / Published: 19 December 2012
Show/Hide Abstract | PDF Full-text (218 KB) | HTML Full-text | XML Full-text

Viruses 2012, 4(12), 3531-3550; doi:10.3390/v4123531
Received: 2 November 2012; in revised form: 18 November 2012 / Accepted: 28 November 2012 / Published: 6 December 2012
Show/Hide Abstract | Cited by 4 | PDF Full-text (601 KB) | HTML Full-text | XML Full-text

Viruses 2012, 4(12), 3281-3302; doi:10.3390/v4123281
Received: 26 October 2012; in revised form: 17 November 2012 / Accepted: 17 November 2012 / Published: 22 November 2012
Show/Hide Abstract | Cited by 5 | PDF Full-text (351 KB) | HTML Full-text | XML Full-text

Viruses 2012, 4(11), 2924-2944; doi:10.3390/v4112924
Received: 1 October 2012; in revised form: 29 October 2012 / Accepted: 5 November 2012 / Published: 8 November 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (457 KB) | HTML Full-text | XML Full-text

Viruses 2012, 4(11), 2598-2635; doi:10.3390/v4112598
Received: 4 September 2012; in revised form: 18 October 2012 / Accepted: 22 October 2012 / Published: 29 October 2012
Show/Hide Abstract | Cited by 14 | PDF Full-text (2639 KB) | HTML Full-text | XML Full-text

Viruses 2012, 4(10), 2340-2358; doi:10.3390/v4102340
Received: 4 September 2012; in revised form: 5 October 2012 / Accepted: 9 October 2012 / Published: 19 October 2012
Show/Hide Abstract | Cited by 9 | PDF Full-text (902 KB) | HTML Full-text | XML Full-text

Viruses 2012, 4(10), 2251-2290; doi:10.3390/v4102251
Received: 31 August 2012; in revised form: 7 October 2012 / Accepted: 9 October 2012 / Published: 19 October 2012
Show/Hide Abstract | Cited by 7 | PDF Full-text (2053 KB) | HTML Full-text | XML Full-text

Viruses 2012, 4(10), 2233-2250; doi:10.3390/v4102233
Received: 27 August 2012; in revised form: 26 September 2012 / Accepted: 1 October 2012 / Published: 19 October 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (477 KB) | HTML Full-text | XML Full-text

Viruses 2012, 4(10), 2197-2217; doi:10.3390/v4102197
Received: 4 September 2012; in revised form: 2 October 2012 / Accepted: 10 October 2012 / Published: 17 October 2012
Show/Hide Abstract | Cited by 10 | PDF Full-text (909 KB) | HTML Full-text | XML Full-text

Viruses 2012, 4(8), 1264-1278; doi:10.3390/v4081264
Received: 12 June 2012; in revised form: 27 July 2012 / Accepted: 6 August 2012 / Published: 14 August 2012
Show/Hide Abstract | Cited by 4 | PDF Full-text (686 KB) | HTML Full-text | XML Full-text

Viruses 2012, 4(4), 581-612; doi:10.3390/v4040581
Received: 7 February 2012; in revised form: 31 March 2012 / Accepted: 3 April 2012 / Published: 16 April 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (1896 KB) | HTML Full-text | XML Full-text | Supplementary Files

Last update: 5 March 2014

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