Next Article in Journal
Virus-Induced Aggregates in Infected Cells
Next Article in Special Issue
RNA Structural Elements of Hepatitis C Virus Controlling Viral RNA Translation and the Implications for Viral Pathogenesis
Previous Article in Journal
Arenavirus Evasion of Host Anti-Viral Responses
Previous Article in Special Issue
Roles of ITPA and IL28B Genotypes in Chronic Hepatitis C Patients Treated with Peginterferon Plus Ribavirin
Article Menu

Export Article

Open AccessReview
Viruses 2012, 4(10), 2197-2217; doi:10.3390/v4102197

Hepatitis C Virus and Natural Compounds: A New Antiviral Approach?

Inserm U1019, CNRS UMR8204, Center for Infection & Immunity of Lille (CIIL), Institut Pasteur de Lille, Université Lille Nord de France, Lille, France
*
Author to whom correspondence should be addressed.
Received: 4 September 2012 / Revised: 2 October 2012 / Accepted: 10 October 2012 / Published: 17 October 2012
(This article belongs to the Special Issue Hepatitis C Pathology)
View Full-Text   |   Download PDF [909 KB, uploaded 12 May 2015]   |  

Abstract

Hepatitis C is a major global health burden with an estimated 160 million infected individuals worldwide. This long-term disease evolves slowly, often leading to chronicity and potentially to liver failure. There is no anti-HCV vaccine, and, until recently, the only treatment available, based on pegylated interferon and ribavirin, was partially effective, and had considerable side effects. With recent advances in the understanding of the HCV life cycle, the development of promising direct acting antivirals (DAAs) has been achieved. Their use in combination with the current treatment has led to encouraging results for HCV genotype 1 patients. However, this therapy is quite expensive and will probably not be accessible for all patients worldwide. For this reason, constant efforts are being made to identify new antiviral molecules. Recent reports about natural compounds highlight their antiviral activity against HCV. Here, we aim to review the natural molecules that interfere with the HCV life cycle and discuss their potential use in HCV therapy. View Full-Text
Keywords: hepatitis C virus; natural molecules; direct acting antivirals; flavonoids hepatitis C virus; natural molecules; direct acting antivirals; flavonoids
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Calland, N.; Dubuisson, J.; Rouillé, Y.; Séron, K. Hepatitis C Virus and Natural Compounds: A New Antiviral Approach? Viruses 2012, 4, 2197-2217.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top