Special Issue "Antivirals Against Poxviruses"

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A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Antivirals & Vaccines".

Deadline for manuscript submissions: closed (31 August 2010)

Special Issue Editor

Guest Editor
Prof. Dr. Earl R. Kern
The University of Alabama at Birmingham, CHB 128, 1600 6th Avenue South, Birmingham, AL 35216, USA
E-Mail: kern@uab.edu
Phone: +1 205 934 1990

Special Issue Information

Dear Colleagues,

Although smallpox was eradicated about 30 years ago, there are continuing concerns regarding the intentional or accidental release of variola virus in a population that has little immunity due to the cessation of universal vaccination programs.
Additionally, the inadvertent importation of monkeypox virus into the United States through the sale of infected rodents reinforced the need for effective therapies that could be used during outbreaks of these infections. In response to these concerns, additional resources have been allocated to the research, discovery and development of new antiviral agents and significant advances have been achieved. At the present time there is no licensed drug for the treatment of any orthopoxvirus infection, however, cidofovir has been approved for use in the emergency treatment of smallpox outbreaks or in complications following vaccination. Two additional molecules, CMX001, an orally active analog of cidofovir, and ST-246, a small molecule, are highly active in vitro and in a variety of experimental orthopoxvirus infections in animals including non-human primates. Neither one has been approved due to the inability to conduct clinical studies for efficacy. This special issue will focus primarily on the development of these promising molecules and particularly on the use of animal model systems used to evaluate new antiviral drugs for treatment of orthopoxvirus infections in humans.

Prof. Dr. Earl R. Kern
Guest Editor

Keywords

  • orthopoxvirus
  • poxvirus
  • antiviral
  • animal model
  • cidofovir
  • CMX001
  • ST-246
  • variola virus
  • monkeypox virus
  • vaccinia virus
  • cowpox virus
  • rabbitpox virus
  • ectromelia virus

Published Papers (13 papers)

by , , , , , ,  and
Viruses 2011, 3(2), 63-82; doi:10.3390/v3020063
Received: 23 December 2010; Accepted: 4 January 2011 / Published: 25 January 2011
Show/Hide Abstract | Cited by 4 | PDF Full-text (1335 KB)

by , , , , , , , , , , , , ,  and
Viruses 2011, 3(1), 47-62; doi:10.3390/v3010047
Received: 1 December 2010; in revised form: 4 January 2011 / Accepted: 5 January 2011 / Published: 24 January 2011
Show/Hide Abstract | Cited by 6 | PDF Full-text (660 KB)

by  and
Viruses 2010, 2(12), 2803-2830; doi:10.3390/v2122803
Received: 10 November 2010; in revised form: 9 December 2010 / Accepted: 10 December 2010 / Published: 22 December 2010
Show/Hide Abstract | Cited by 8 | PDF Full-text (315 KB)
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by  and
Viruses 2010, 2(12), 2763-2776; doi:10.3390/v2122763
Received: 10 November 2010; in revised form: 8 December 2010 / Accepted: 10 December 2010 / Published: 20 December 2010
Show/Hide Abstract | Cited by 1 | PDF Full-text (219 KB)

by , , , , , , , , ,  and
Viruses 2010, 2(12), 2740-2762; doi:10.3390/v2122740
Received: 28 October 2010; in revised form: 17 November 2010 / Accepted: 22 November 2010 / Published: 17 December 2010
Show/Hide Abstract | Cited by 13 | PDF Full-text (439 KB)

by  and
Viruses 2010, 2(12), 2681-2695; doi:10.3390/v2122681
Received: 8 November 2010; in revised form: 6 December 2010 / Accepted: 6 December 2010 / Published: 13 December 2010
Show/Hide Abstract | Cited by 6 | PDF Full-text (245 KB)

by , ,  and
Viruses 2010, 2(11), 2409-2435; doi:10.3390/v2112409
Received: 18 September 2010; in revised form: 26 October 2010 / Accepted: 26 October 2010 / Published: 3 November 2010
Show/Hide Abstract | Cited by 8 | PDF Full-text (422 KB)

by  and
Viruses 2010, 2(10), 2381-2403; doi:10.3390/v2102381
Received: 19 September 2010; in revised form: 9 October 2010 / Accepted: 13 October 2010 / Published: 20 October 2010
Show/Hide Abstract | Cited by 2 | PDF Full-text (101 KB)

by
Viruses 2010, 2(10), 2213-2225; doi:10.3390/v2102213
Received: 26 August 2010; in revised form: 8 September 2010 / Accepted: 8 September 2010 / Published: 30 September 2010
Show/Hide Abstract | Cited by 10 | PDF Full-text (135 KB)

by  and
Viruses 2010, 2(9), 2096-2107; doi:10.3390/v2092096
Received: 26 August 2010; in revised form: 2 September 2010 / Accepted: 8 September 2010 / Published: 27 September 2010
Show/Hide Abstract | Cited by 5 | PDF Full-text (855 KB)

by  and
Viruses 2010, 2(9), 1968-1983; doi:10.3390/v2091968
Received: 5 August 2010; in revised form: 20 August 2010 / Accepted: 7 September 2010 / Published: 16 September 2010
Show/Hide Abstract | Cited by 4 | PDF Full-text (306 KB)

by , , ,  and
Viruses 2010, 2(9), 1918-1932; doi:10.3390/v2091918
Received: 2 July 2010; in revised form: 30 August 2010 / Accepted: 31 August 2010 / Published: 3 September 2010
Show/Hide Abstract | Cited by 5 | PDF Full-text (759 KB)

by
Viruses 2010, 2(6), 1322-1339; doi:10.3390/v2061322
Received: 19 April 2010; in revised form: 28 May 2010 / Accepted: 28 May 2010 / Published: 14 June 2010
Show/Hide Abstract | Cited by 5 | PDF Full-text (859 KB) | XML Full-text | Supplementary Files

Last update: 5 March 2014

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