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Viruses 2010, 2(6), 1322-1339; doi:10.3390/v2061322
Review

Historical Perspectives in the Development of Antiviral Agents Against Poxviruses

Received: 19 April 2010; in revised form: 28 May 2010 / Accepted: 28 May 2010 / Published: 14 June 2010
(This article belongs to the Special Issue Antivirals Against Poxviruses)
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Abstract: The poxvirus vaccinia virus (VV) served as the model virus for which the first antivirals, the thiosemicarbazones, were identified. This dates back to 1950; and, although there is at present no single antiviral drug specifically licensed for the chemotherapy or -prophylaxis of poxvirus infections, numerous candidate compounds have been described over the past 50 years. These compounds include interferon and inducers thereof (i.e., polyacrylic acid), 5-substituted 2’-deoxyuridines (i.e., idoxuridine), IMP dehydrogenase inhibitors, S-adenosylhomocysteine hydrolase inhibitors, acyclic nucleoside phosphonates (such as cidofovir) and alkoxyalkyl prodrugs thereof (such as CMX001), viral egress inhibitors (such as tecovirimat), and cellular kinase inhibitors (such as imatinib).
Keywords: thiosemicarbazones; interferon (inducers); idoxuridine (IDU); acyclic nucleoside phosphonates; cidofovir; CMX001 (HDP-CDV); tecovirimat (ST-246); Gleevec (imatinib) thiosemicarbazones; interferon (inducers); idoxuridine (IDU); acyclic nucleoside phosphonates; cidofovir; CMX001 (HDP-CDV); tecovirimat (ST-246); Gleevec (imatinib)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

De Clercq, E. Historical Perspectives in the Development of Antiviral Agents Against Poxviruses. Viruses 2010, 2, 1322-1339.

AMA Style

De Clercq E. Historical Perspectives in the Development of Antiviral Agents Against Poxviruses. Viruses. 2010; 2(6):1322-1339.

Chicago/Turabian Style

De Clercq, Erik. 2010. "Historical Perspectives in the Development of Antiviral Agents Against Poxviruses." Viruses 2, no. 6: 1322-1339.


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