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Monkeypox Virus Infections in Small Animal Models for Evaluation of Anti-Poxvirus Agents
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd. MS-G06 Atlanta, GA 30029, USA
* Author to whom correspondence should be addressed.
Received: 10 November 2010; in revised form: 8 December 2010 / Accepted: 10 December 2010 / Published: 20 December 2010
Abstract: An ideal animal model for the study of a human disease is one which utilizes a route of infection that mimics the natural transmission of the pathogen; the ability to obtain disease with an infectious dose equivalent to that causing disease in humans; as well having a disease course, morbidity and mortality similar to that seen with human disease. Additionally, the animal model should have a mode(s) of transmission that mimics human cases. The development of small animal models for the study of monkeypox virus (MPXV) has been quite extensive for the relatively short period of time this pathogen has been known, although only a few of these models have been used to study anti-poxvirus agents. We will review those MPXV small animal models that have been developed thus far for the study of therapeutic agents.
Keywords: monkeypox; animal models; therapeutics
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Hutson, C.L.; Damon, I.K. Monkeypox Virus Infections in Small Animal Models for Evaluation of Anti-Poxvirus Agents. Viruses 2010, 2, 2763-2776.
Hutson CL, Damon IK. Monkeypox Virus Infections in Small Animal Models for Evaluation of Anti-Poxvirus Agents. Viruses. 2010; 2(12):2763-2776.
Hutson, Christina L.; Damon, Inger K. 2010. "Monkeypox Virus Infections in Small Animal Models for Evaluation of Anti-Poxvirus Agents." Viruses 2, no. 12: 2763-2776.