CiteULike
Facebook
Mendeley
Twitter
This article is- freely available
- re-usable
Viruses 2010, 2(12), 2763-2776; doi:10.3390/v2122763
Review
Monkeypox Virus Infections in Small Animal Models for Evaluation of Anti-Poxvirus Agents
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd. MS-G06 Atlanta, GA 30029, USA
* Author to whom correspondence should be addressed.
Received: 10 November 2010; in revised form: 8 December 2010 / Accepted: 10 December 2010 / Published: 20 December 2010
(This article belongs to the Special Issue Antivirals Against Poxviruses)
Download PDF Full-Text [219 KB, uploaded 20 December 2010 16:23 CET]
Abstract: An ideal animal model for the study of a human disease is one which utilizes a route of infection that mimics the natural transmission of the pathogen; the ability to obtain disease with an infectious dose equivalent to that causing disease in humans; as well having a disease course, morbidity and mortality similar to that seen with human disease. Additionally, the animal model should have a mode(s) of transmission that mimics human cases. The development of small animal models for the study of monkeypox virus (MPXV) has been quite extensive for the relatively short period of time this pathogen has been known, although only a few of these models have been used to study anti-poxvirus agents. We will review those MPXV small animal models that have been developed thus far for the study of therapeutic agents.
Keywords: monkeypox; animal models; therapeutics
Article Statistics
Click here to load and display the download statistics.Cite This Article
MDPI and ACS Style
Hutson, C.L.; Damon, I.K. Monkeypox Virus Infections in Small Animal Models for Evaluation of Anti-Poxvirus Agents. Viruses 2010, 2, 2763-2776.
AMA StyleHutson CL, Damon IK. Monkeypox Virus Infections in Small Animal Models for Evaluation of Anti-Poxvirus Agents. Viruses. 2010; 2(12):2763-2776.
Chicago/Turabian StyleHutson, Christina L.; Damon, Inger K. 2010. "Monkeypox Virus Infections in Small Animal Models for Evaluation of Anti-Poxvirus Agents." Viruses 2, no. 12: 2763-2776.