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Special Issue "6th Pan-American Dengue Research Network Meeting"

A special issue of Viruses (ISSN 1999-4915).

Deadline for manuscript submissions: 30 June 2018

Special Issue Editors

Guest Editor
Assoc. Prof. Nikolaos Vasilakis

Department of Pathology and Center of Biodefense and Emerging Infectious Diseases; Center for Tropical Diseases; and Institute for Human Infection and Immunity University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0609, USA
Website | E-Mail
Interests: basic research on evolution and pathogenesis of arthropod-borne viruses; quasispecies in transmission dynamics and emergence; and discovery and characterization of novel/new viruses
Guest Editor
Dr. Carlos A. Sariol

Unit of Comparative Medicine, Caribbean Primate Research Center, Department of Microbiology and Medical Zoology, Department of Internal Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, USA
Website1 | Website2 | E-Mail
Interests: basic research on flavivirus interactions at molecular level and pathogenesis; vaccine development and characterization of novel viruses in non human primate model; also interested and actively involved in clinical trials for several diseases including flavivirus vaccines

Special Issue Information

Dear Colleagues,

The Pan-American Dengue Research Network Meeting (http://www.pandenguenet.org) is an initiative to gather researchers across the Americas every two years to discuss their recent advancements in the field, communicate this information to the scientific community in the region, foster collaborations among groups, and discuss future research strategies that will further strengthen the field. During these meetings, cutting-edge topics on dengue field are presented and discussed. One of the main objectives of this application is to guarantee the participation of many graduate students and junior investigators from Latin American and Caribbean regions, which have been usually underrepresented in science. The scientific meeting to be held for the first time in the US and undoubtedly will make an important contribution to supporting and broadening the impact of research on dengue throughout the hemisphere. Additionally, for this meeting the scientific scope will be expanded to cover Zika, chikungunya and Mayaro, arboviroses that have recently re-emerged in the Americas with devastating effects for human public health. Lastly, we will celebrate and honor the contributions of Robert Tesh and Hilda Guzman to arbovirology, both of whom have recently retired after 30 years as curators of the World Reference Collection of Emerging Viruses and Arboviruses (WRCEVA). The collection of reviews and original research papers in this Special Issue is intended to summarize and showcase current research on arboviruses by investigators from throughout the Americas.

Assoc. Prof. Nikolaos Vasilakis
Dr. Carlos A. Sariol
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Dengue
  • Zika
  • Chikungunya
  • Yellow fever
  • Mayaro
  • vaccine
  • pathogenesis
  • immunology
  • virology

Published Papers (1 paper)

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Open AccessArticle Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue
Viruses 2018, 10(3), 104; doi:10.3390/v10030104
Received: 2 February 2018 / Revised: 23 February 2018 / Accepted: 25 February 2018 / Published: 28 February 2018
PDF Full-text (3091 KB) | HTML Full-text | XML Full-text
The inflammatory process plays a major role in the prognosis of dengue. In this context, the eicosanoids may have considerable influence on the regulation of the Dengue virus-induced inflammatory process. To quantify the molecules involved in the cyclooxygenase and lipoxygenase pathways during
[...] Read more.
The inflammatory process plays a major role in the prognosis of dengue. In this context, the eicosanoids may have considerable influence on the regulation of the Dengue virus-induced inflammatory process. To quantify the molecules involved in the cyclooxygenase and lipoxygenase pathways during Dengue virus infection, plasma levels of thromboxane A2, prostaglandin E2 and leukotriene B4; mRNA levels of thromboxane A2 synthase, prostaglandin E2 synthase, leukotriene A4 hydrolase, cyclooxygenase-2 and 5-lipoxygenase; and the levels of lipid bodies in peripheral blood leukocytes collected from IgM-positive and IgM-negative volunteers with mild dengue, and non-infected volunteers, were evaluated. Dengue virus infection increases the levels of thromboxane A2 in IgM-positive individuals as well as the amount of lipid bodies in monocytes in IgM-negative individuals. We suggest that increased levels of thromboxane A2 in IgM-positive individuals plays a protective role against the development of severe symptoms of dengue, such as vascular leakage. Full article
(This article belongs to the Special Issue 6th Pan-American Dengue Research Network Meeting)

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