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Special Issue "6th Pan-American Dengue Research Network Meeting"

A special issue of Viruses (ISSN 1999-4915).

Deadline for manuscript submissions: 30 September 2018

Special Issue Editors

Guest Editor
Assoc. Prof. Nikolaos Vasilakis

Department of Pathology and Center of Biodefense and Emerging Infectious Diseases; Center for Tropical Diseases; and Institute for Human Infection and Immunity University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0609, USA
Website | E-Mail
Interests: basic research on evolution and pathogenesis of arthropod-borne viruses; quasispecies in transmission dynamics and emergence; and discovery and characterization of novel/new viruses
Guest Editor
Dr. Carlos A. Sariol

Unit of Comparative Medicine, Caribbean Primate Research Center, Department of Microbiology and Medical Zoology, Department of Internal Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, USA
Website 1 | Website 2 | E-Mail
Interests: basic research on flavivirus interactions at molecular level and pathogenesis; vaccine development and characterization of novel viruses in non human primate model; also interested and actively involved in clinical trials for several diseases including flavivirus vaccines

Special Issue Information

Dear Colleagues,

The Pan-American Dengue Research Network Meeting (http://www.pandenguenet.org) is an initiative to gather researchers across the Americas every two years to discuss their recent advancements in the field, communicate this information to the scientific community in the region, foster collaborations among groups, and discuss future research strategies that will further strengthen the field. During these meetings, cutting-edge topics on dengue field are presented and discussed. One of the main objectives of this application is to guarantee the participation of many graduate students and junior investigators from Latin American and Caribbean regions, which have been usually underrepresented in science. The scientific meeting to be held for the first time in the US and undoubtedly will make an important contribution to supporting and broadening the impact of research on dengue throughout the hemisphere. Additionally, for this meeting the scientific scope will be expanded to cover Zika, chikungunya and Mayaro, arboviroses that have recently re-emerged in the Americas with devastating effects for human public health. Lastly, we will celebrate and honor the contributions of Robert Tesh and Hilda Guzman to arbovirology, both of whom have recently retired after 30 years as curators of the World Reference Collection of Emerging Viruses and Arboviruses (WRCEVA). The collection of reviews and original research papers in this Special Issue is intended to summarize and showcase current research on arboviruses by investigators from throughout the Americas.

Assoc. Prof. Nikolaos Vasilakis
Dr. Carlos A. Sariol
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Dengue
  • Zika
  • Chikungunya
  • Yellow fever
  • Mayaro
  • vaccine
  • pathogenesis
  • immunology
  • virology

Published Papers (3 papers)

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Research

Open AccessArticle NS1 Antigenemia and Viraemia Load: Potential Markers of Progression to Dengue Fatal Outcome?
Viruses 2018, 10(6), 326; https://doi.org/10.3390/v10060326
Received: 3 January 2018 / Revised: 22 February 2018 / Accepted: 1 March 2018 / Published: 14 June 2018
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Abstract
Dengue is a worldwide problem characterized by a multifactorial pathogenesis. Considering the viral components, it is known that high viremia or high levels of the secreted nonstructural protein 1 (NS1) may be associated with a more severe disease. We aimed to characterize the
[...] Read more.
Dengue is a worldwide problem characterized by a multifactorial pathogenesis. Considering the viral components, it is known that high viremia or high levels of the secreted nonstructural protein 1 (NS1) may be associated with a more severe disease. We aimed to characterize the NS1 antigenemia and viremia in dengue fatal and non-fatal cases, as potential markers of progression to a fatal outcome. NS1 antigenemia and viremia were determined in Brazilian dengue fatal cases (n = 40) and non-fatal cases (n = 40), representative of the four dengue virus (DENV) serotypes. Overall, the fatal cases presented higher NS1 levels and viremia. Moreover, the fatal cases from secondary infections showed significantly higher NS1 levels than the non-fatal ones. Here, irrespective of the disease outcome, DENV-1 cases presented higher NS1 levels than the other serotypes. However, DENV-2 and DENV-4 fatal cases had higher NS1 antigenemia than the non-fatal cases with the same serotype. The viremia in the fatal cases was higher than in the non-fatal ones, with DENV-3 and DENV-4 presenting higher viral loads. Viral components, such as NS1 and viral RNA, may be factors influencing the disease outcome. However, the host immune status, comorbidities, and access to adequate medical support cannot be ruled out as interfering in the disease outcome. Full article
(This article belongs to the Special Issue 6th Pan-American Dengue Research Network Meeting)
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Figure 1a

Open AccessArticle Molecular and Clinical Characterization of Chikungunya Virus Infections in Southeast Mexico
Viruses 2018, 10(5), 248; https://doi.org/10.3390/v10050248
Received: 23 March 2018 / Revised: 29 April 2018 / Accepted: 30 April 2018 / Published: 9 May 2018
PDF Full-text (7623 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Chikungunya fever is an arthropod-borne infection caused by Chikungunya virus (CHIKV). Even though clinical features of Chikungunya fever in the Mexican population have been described before, there is no detailed information. The aim of this study was to perform a full description of
[...] Read more.
Chikungunya fever is an arthropod-borne infection caused by Chikungunya virus (CHIKV). Even though clinical features of Chikungunya fever in the Mexican population have been described before, there is no detailed information. The aim of this study was to perform a full description of the clinical features in confirmed Chikungunya-infected patients and describe the molecular epidemiology of CHIKV. We evaluated febrile patients who sought medical assistance in Tapachula, Chiapas, Mexico, from June through July 2015. Infection was confirmed with molecular and serological methods. Viruses were isolated and the E1 gene was sequenced. Phylogeny reconstruction was inferred using maximum-likelihood and maximum clade credibility approaches. We studied 52 patients with confirmed CHIKV infection. They were more likely to have wrist, metacarpophalangeal, and knee arthralgia. Two combinations of clinical features were obtained to differentiate between Chikungunya fever and acute undifferentiated febrile illness. We obtained 10 CHIKV E1 sequences that grouped with the Asian lineage. Seven strains diverged from the formerly reported. Patients infected with the divergent CHIKV strains showed a broader spectrum of clinical manifestations. We defined the complete clinical features of Chikungunya fever in patients from Southeastern Mexico. Our results demonstrate co-circulation of different CHIKV strains in the state of Chiapas. Full article
(This article belongs to the Special Issue 6th Pan-American Dengue Research Network Meeting)
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Graphical abstract

Open AccessArticle Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue
Viruses 2018, 10(3), 104; https://doi.org/10.3390/v10030104
Received: 2 February 2018 / Revised: 23 February 2018 / Accepted: 25 February 2018 / Published: 28 February 2018
PDF Full-text (3091 KB) | HTML Full-text | XML Full-text
Abstract
The inflammatory process plays a major role in the prognosis of dengue. In this context, the eicosanoids may have considerable influence on the regulation of the Dengue virus-induced inflammatory process. To quantify the molecules involved in the cyclooxygenase and lipoxygenase pathways during
[...] Read more.
The inflammatory process plays a major role in the prognosis of dengue. In this context, the eicosanoids may have considerable influence on the regulation of the Dengue virus-induced inflammatory process. To quantify the molecules involved in the cyclooxygenase and lipoxygenase pathways during Dengue virus infection, plasma levels of thromboxane A2, prostaglandin E2 and leukotriene B4; mRNA levels of thromboxane A2 synthase, prostaglandin E2 synthase, leukotriene A4 hydrolase, cyclooxygenase-2 and 5-lipoxygenase; and the levels of lipid bodies in peripheral blood leukocytes collected from IgM-positive and IgM-negative volunteers with mild dengue, and non-infected volunteers, were evaluated. Dengue virus infection increases the levels of thromboxane A2 in IgM-positive individuals as well as the amount of lipid bodies in monocytes in IgM-negative individuals. We suggest that increased levels of thromboxane A2 in IgM-positive individuals plays a protective role against the development of severe symptoms of dengue, such as vascular leakage. Full article
(This article belongs to the Special Issue 6th Pan-American Dengue Research Network Meeting)
Figures

Graphical abstract

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