Role of Nk Cells and Non-nk Ilcs in Disease Progression and Their Application as Targets for Immune Interventions

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Cellular/Molecular Immunology".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 3347

Special Issue Editor


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Guest Editor
Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
Interests: innate lymphoid cells; adaptive immunity; murine infection models; applied human research studies; immune profiling; vaccines

Special Issue Information

Dear Colleagues,

The new emerging insights into NK cell biology (e.g. adaptive immune features) in the last decades as well as the discovery of novel ILC subsets advocate them as potential targets to combat infectious diseases. Although the impact of NK cells and non-NK ILCs on the generation of adaptive immune responses has been described, they are still largely neglected concerning their impact on the establishment of new immune interventions aimed at preventing or treating infectious diseases. However, their described double-edged role in the course of infections requires special attention to define their range of application. We are therefore happy to announce a vaccines special issue dealing with the role of NK cells and non-NK ILCs in the context of infectious diseases with a special focus on their impact for the establishment of prophylactic or therapeutic immune interventions. We encourage the presentation of new findings and advances in this field of research that will contribute to the advancement of inventive modern medical approaches. These findings might encompass host-pathogen interactions or mechanisms of action in the context of murine infection or immunization studies as well as applied research and clinical studies.     

Dr. Peggy Riese
Guest Editor

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Keywords

  • NK cells
  • Non-NK ILCs
  • Infectious Diseases
  • Immune Interventions
  • Inflammation
  • Immune regulation Plasticity
  • Murine infection models
  • Clinical research studies

Published Papers (1 paper)

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Review

12 pages, 695 KiB  
Review
Natural Killer Cell Responses during Human γ-Herpesvirus Infections
by Christian Münz
Vaccines 2021, 9(6), 655; https://doi.org/10.3390/vaccines9060655 - 15 Jun 2021
Cited by 7 | Viewed by 2981
Abstract
Herpesviruses are main sculptors of natural killer (NK) cell repertoires. While the β-herpesvirus human cytomegalovirus (CMV) drives the accumulation of adaptive NKG2C-positive NK cells, the human γ-herpesvirus Epstein–Barr virus (EBV) expands early differentiated NKG2A-positive NK cells. While adaptive NK cells support adaptive immunity [...] Read more.
Herpesviruses are main sculptors of natural killer (NK) cell repertoires. While the β-herpesvirus human cytomegalovirus (CMV) drives the accumulation of adaptive NKG2C-positive NK cells, the human γ-herpesvirus Epstein–Barr virus (EBV) expands early differentiated NKG2A-positive NK cells. While adaptive NK cells support adaptive immunity by antibody-dependent cellular cytotoxicity, NKG2A-positive NK cells seem to preferentially target lytic EBV replicating B cells. The importance of this restriction of EBV replication during γ-herpesvirus pathogenesis will be discussed. Furthermore, the modification of EBV-driven NK cell expansion by coinfections, including by the other human γ-herpesvirus Kaposi sarcoma-associated herpesvirus (KSHV), will be summarized. Full article
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