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Special Issue "Bacterial Pore-Forming Toxins"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 30 June 2018

Special Issue Editor

Guest Editor
Dr. Peter A. Keyel

Department of Biological Sciences, Texas Tech University, Box 43131 Lubbock, TX 79409 USA
Website | E-Mail
Interests: cholesterol-dependent cytolysin; membrane repair; inflammasome; macrophage; Dnase1L3

Special Issue Information

Dear Colleagues,

Pore-forming toxins (PFTs) are the largest family of bacterial toxins. They are extensively involved in the virulence of many lethal Gram positive and Gram negative bacterial infections. In some cases, their impacts appear to be independent of target cell lysis, suggesting that PFTs may affect target cells in multiple ways. Similarly, nonpathogenic bacteria also utilize a range of PFTs, indicating that PFTs provide bacteria with a survival advantage beyond pathogenesis. The evolutionary advantages of PFTs are not limited to bacteria. Bacterial PFTs bear strong structural and three-dimensional similarities to PFTs used by other organisms, and have served effectively as tools for answering broad, fundamental questions about PFT structure and mechanism of action. Three such broad outstanding questions in the field are: How do bacterial PFTs promote bacterial fitness beyond lysis of target cells? What mechanisms do competing bacteria, hosts and other organisms use to react to bacterial PFTs? Which insights and mechanisms from bacterial PFTs are also relevant to PFTs from humans and other organisms?

This Special Issue will focus on the interaction of bacterial pore forming toxins with their targets, the functional outcomes of these interactions, and target responses to these toxins. Nonlethal toxin-target interactions, and novel insights into toxin structure/function are areas of special interest.

Dr. Peter A. Keyel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • pore-forming toxin
  • cholesterol-dependent cytolysin
  • hemolysin
  • host-pathogen interaction
  • membrane repair
  • cell death

Published Papers

This special issue is now open for submission.
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