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Toxins 2018, 10(6), 234; https://doi.org/10.3390/toxins10060234

Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins

Biofisika Institute (UPV/EHU, CSIC) and University of the Basque Country (UPV/EHU) Parque Científico s/n, 48940 Leioa, Spain
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Received: 24 May 2018 / Revised: 4 June 2018 / Accepted: 7 June 2018 / Published: 9 June 2018
(This article belongs to the Special Issue Bacterial Pore-Forming Toxins)
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Abstract

Permeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis. Numerous pathogenic bacteria produce pore-forming toxins that break plasma membrane integrity and cause cell death by colloid-osmotic lysis. Eukaryotic cells, in turn, have developed different ways to cope with the effects of such membrane piercing. Here, we provide a short overview of the general mechanisms currently proposed for plasma membrane repair, focusing more specifically on the cellular responses to membrane permeabilization by pore-forming toxins and presenting new data on the effects and cellular responses to the permeabilization by an RTX (repeats in toxin) toxin, the adenylate cyclase toxin-hemolysin secreted by the whooping cough bacterium Bordetella pertussis, which we have studied in the laboratory. View Full-Text
Keywords: membrane permeabilization; membrane repair; pore-forming toxins; RTX toxins; adenylate cyclase toxin; Bordetella pertussis membrane permeabilization; membrane repair; pore-forming toxins; RTX toxins; adenylate cyclase toxin; Bordetella pertussis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Etxaniz, A.; González-Bullón, D.; Martín, C.; Ostolaza, H. Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins. Toxins 2018, 10, 234.

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