Special Issue "Bacterial Protein Toxins"
Deadline for manuscript submissions: closed (30 November 2009)
Dr. Yasuhiko Horiguchi
Research Institute for Microbial Diseases, Osaka University, Yamada-oka 3-1, Suita, Osaka 565-0871, Japan
Phone: +81 6 6879 8284
Fax: + 81 6 6879 8283
Interests: structure and domain organization of proteins; cell-to -cell or intracellular signaling; receptors for toxins; membrane-damaging toxins
Dr. Yukako Fujinaga
Laboratory for Infection Cell Biology, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Yamada-oka 3-1, Suita, Osaka 565-0871, Japan
Phone: +81 6 6879 4250
Fax: +81 6 6879 4252
Interests: bacterial protein toxins; enterotoxins; mechanism of toxicity; interaction of toxins with epithelial cell barriers
Bacterial protein toxins play an important role in infectious diseases. Several are highly potent human poisons, such as botulinum, tetanus, Shiga, and diphtheria toxins. These toxins are multi-functional proteins that are self-programmed to reach their target organs and/or enter cells. Another set of toxins is called effector, which is directly delivered into the cell by type III/IV mechanisms. To exert their potency, many of them interact specifically with key components of the cell. Thus, these toxins are not only responsible for disease, but also provide a powerful set of tools with which to elucidate complicated machinery of the cell system. In addition, some toxins can be used medicinally to treat human diseases, such as Botox (botulinum toxin) in recent years. This issue of Toxins will deal with major achievements and recent exciting discoveries in protein toxins and effectors produced by bacteria, including three-dimensional structures, structure-activity relationships, toxin receptors, toxin substrates, toxin trafficking, and clinical applications.
Yukako Fujinaga, Ph. D.
Yasuhiko Horiguchi, Ph. D.
- virulence factor
- pore formation
- effector protein