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Toxins 2009, 1(2), 208-228; doi:10.3390/toxins1020208

Clostridium perfringens Iota-Toxin: Structure and Function

1
Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan
2
Institute for Health Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan
*
Author to whom correspondence should be addressed.
Received: 27 November 2009 / Revised: 16 December 2009 / Accepted: 21 December 2009 / Published: 23 December 2009
(This article belongs to the Special Issue Bacterial Protein Toxins)
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Abstract

Clostridium perfringens iota-toxin is composed of the enzyme component (Ia) and the binding component (Ib). Ib binds to receptor on targeted cells and translocates Ia into the cytosol of the cells. Ia ADP-ribosylates actin, resulting in cell rounding and death. Comparisons of the deduced amino acid sequence from the gene and three-dimensional structure of Ia with those of ADP-ribosylating toxins (ARTs) suggests that there is striking structural similarity among these toxins. Our objectives are to review the recent advances in the character, structure-function, and the mode of action of iota-toxin by consideration of the findings about ARTs.
Keywords: Clostridium perfringens; iota-toxin; ADP-ribosylating toxin; NAD+-glycohydrolase; ADP-ribosyltransferase; crystal structure; SN1 mechanism; internalization; endocytosis Clostridium perfringens; iota-toxin; ADP-ribosylating toxin; NAD+-glycohydrolase; ADP-ribosyltransferase; crystal structure; SN1 mechanism; internalization; endocytosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Sakurai, J.; Nagahama, M.; Oda, M.; Tsuge, H.; Kobayashi, K. Clostridium perfringens Iota-Toxin: Structure and Function. Toxins 2009, 1, 208-228.

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