Special Issue "Exposure to Airborne Toxics in Biological Populations and Implications for Health"

A special issue of Toxics (ISSN 2305-6304).

Deadline for manuscript submissions: closed (31 August 2014)

Special Issue Editors

Guest Editor
Prof. Dr. James Jay Schauer

University Wisconsin, Environ Chem & Technol Program, 660 N Pk St, Madison, WI 53706, USA
Website | E-Mail
Interests: atmospheric chemistry; source apportionment; measurement of atmospheric pollutants; measurement of air pollution source emissions; atmospheric aerosols; atmospheric mercury; trace metals in the environment and redox cycling of metals; air quality in developing and underdeveloped nations
Guest Editor
Prof. Jill Baumgartner

Institute for Health & Social Policy, Department of Epidemiology, Biostatistics & Occupational Health, McGill University, 1130 Pine Avenue W, Montreal, Quebec, H3A 1A3, Canada
Website | E-Mail
Interests: cardiovascular disease; environmental health; epidemiology; exposure assessment; household air pollution; pollution composition and health; rural energy interventions

Special Issue Information

Dear Colleagues,

Air pollution health studies have demonstrated a consistent increased risk for a number of adverse health outcomes in relation to both short- and long-term air pollution exposures in biological populations. However, many of these studies use air pollution metrics that lack specificity and are highly correlated with airborne toxic compounds resulting from the fact that they are emitted from common sources (i.e. roadways, Industrial facilities) or meteorological effects. As a result, our current understanding of airborne toxics fails to provide sufficient information to guide air pollution control strategies to best protect human health. Recent advances in exposure assessment, toxicology, and epidemiological methods, and the better integration of tools from these disciplines are helping to better inform which toxics in air pollution are most harmful to biological populations and facilitate more targeted approaches to removing the most toxic components of air pollution. This special issue will bring together current research on airborne toxics that help elucidate the impacts of these pollutants on biological systems and human health outcomes. Original research that demonstrates advances in the development of methods and novel applications of exposure assessment, air pollution epidemiology, and air pollution toxicology are being solicited to contribute to this special issue.

Prof. James Jay Schauer
Prof. Jill Baumgartner
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • biomarkers
  • exposure assessment
  • air toxics
  • multi-pollutant atmosphere
  • environmental health

Published Papers (1 paper)

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Open AccessArticle Short-Term Traffic-Related Exposures and Biomarkers of Nitro-PAH Exposure and Oxidative DNA Damage
Toxics 2014, 2(3), 377-390; doi:10.3390/toxics2030377
Received: 12 May 2014 / Revised: 27 June 2014 / Accepted: 11 July 2014 / Published: 22 July 2014
Cited by 6 | PDF Full-text (487 KB) | HTML Full-text | XML Full-text
Exposure to vehicle exhaust has been associated with cardiac and respiratory disease, lung cancer and greater overall mortality. We investigated whether amino-polycyclic aromatic hydrocarbon (amino-PAH) metabolites of nitro-PAHs could be used as biomarkers of these exposures. Pre- and post-shift urine samples were collected
[...] Read more.
Exposure to vehicle exhaust has been associated with cardiac and respiratory disease, lung cancer and greater overall mortality. We investigated whether amino-polycyclic aromatic hydrocarbon (amino-PAH) metabolites of nitro-PAHs could be used as biomarkers of these exposures. Pre- and post-shift urine samples were collected at the beginning and end of a work week from 82 male U.S. trucking industry workers. We used repeated-measures analysis to examine associations of total 1- and 2-aminonaphthalene (1 & 2-AN) and 1-aminopyrene (1-AP) urinary concentrations with microenvironment exposures to particulate matter (PM2.5), elemental and organic carbon and between 1 & 2-AN and 1-AP with urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG). There was an association between work week mean PM2.5 levels and post-shift 1 & 2-AN (141.8 pg/mL increase (95% CI: 53.3, 230.2) for each IQR increase (5.54 µg/m3) in PM2.5), but no associations with other exposure measures. There was a statistically significant increase in 8-OHdG concentrations with 1 & 2-AN (2.38 µg/mg creatinine (95% CI: 0.19, 4.58) per 242.85 pg/mg creatinine increase in 1 & 2-AN) and suggestive associations with all other exposure measures. Our findings suggest associations between urinary amino-PAHs with vehicle exhaust-related PM2.5, as well as with a biomarker of oxidative DNA damage. Full article

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type: Article
Title: Health Risks Associated with Exposure to PAHs in a Hot Spot of Air Pollution in Camden, NJ
Authors: Xianlei Zhu1, Xiangmei Wu2, Paul Lioy3 and Zhihua (Tina) Fan3
1College of Geosciences, China University of Petroleum-Beijing, Beijing, China
2Department of Public Health, University of California, Davis, California, USA
3Environmental and Occupational Medicine, Robert Wood Johnson Medical School, Environmental and Occupational Health Sciences Institute (EOHSI), Rutgers University, Piscataway, NJ 08854, USA; Correspondence to: Dr. Zhihua (Tina) Fan
Address: Exposure Science Division, Environmental and Occupational Health Sciences Institute (EOHSI), Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA; Tel: (848) 445-3194 Fax: (732) 445-0915 Email: zfan@eohsi.rutgers.edu
Abstract: PAHs data measured at community level are very limited, because PAHs have not been listed as routine monitoring species by the US EPA air quality monitoring programs. Due to the lack of data, health risk assessment associated with exposure to PAHs estimated from regional ambient air quality data or the modeled exposure levels using air toxics emissions data may not be representative for the population living in a hot spot of air pollution. This study will estimate individual cancer and non-cancer risks and accumulative risks using the neighborhood ambient and personal concentrations of PAHs measured in two neighborhoods in Camden, NJ, suspected hotspots of air pollution. To calculate cancer risks, US EPA conventional approaches will be applied to the ambient and personal air pollutants concentrations measured in the study area. To evaluate cumulative cancer risks associated with exposures to the target PAHs for each study participant, compound-specific cancer risk estimates for all of the known, probable, and possible carcinogenic species will be summed. Noncancer risk will be calculated by a direct comparison of the exposure of each participant with a chemical-specific noncancer “health benchmark”. Cumulative noncancer risk will be assessed by aggregating the chemical-specific noncancer risks across the species that affects the same target organ. The results will be compared to those conducted in the hot spot of air pollution as well as those estimated from the EPA ambient air quality monitoring data, and the factors that may affect the estimates of risks in different studies will be discussed. Furthermore, this study will identify the major chemical species contributing to the risk and local outdoor sources that contribute to those risks. Such information will be helpful for policy-making related to air pollution control, particularly in a hot spot of air pollution.

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