Special Issue "Developmental Neurotoxicology"
A special issue of Toxics (ISSN 2305-6304).
Deadline for manuscript submissions: 15 May 2014
Professor David R. Wallace
Oklahoma State University, Center for Health Sciences, 1111 West 17th Street, Tulsa, Oklahoma 74107-1898, USA
Phone: +918 561 1407 Cell: +918 230 8524
Fax: +918 561 5729 Lab: +918 561 5784
Interests: environmental toxins; heavy metals; pesticides; developmental neurotoxicity; neurochemical & cellular mechanisms of toxicity
There has been heightened awareness of neuroscience research since the “Decade of the Brain” which ran from 1990–2000. Significant advances have been made in many areas of brain research from behavioral to degenerative, yet work in developmental neurotoxicology (DNT) has lagged. First, there is the difficulty of translating animal/alternate model systems to the human condition that has slowed progress in this field. The developing brain is extremely sensitive to insult from exogenous xenobiotics. Of the 1,000’s of chemicals that are commercially available, only about 200–300 have known DNT properties. The list of nearly 100 well established toxic compounds includes compounds from heavy metals (cadmium and methylmercury), to prescription drugs (haloperidol and diazepam), and legal ‘drugs’ (caffeine and salicylate), as well as illicit drugs (cocaine and LSD). Approximately 100 compounds have minimal or incomplete evidence of DNT which includes some pesticides (organophosphates), prescription drugs and a variety of other chemicals. It is clear that the developing brain is highly susceptible to toxic insult, yet this sensitivity is not confined to in utero exposure, but also throughout infant, toddler, and pre-teen adolescent neurodevelopment. Contrary to mixtures of many different chemicals found in commercially available preparations or in the environment, neurotoxicity testing consists of examining a single compound. This is a confounding element that needs to be addressed in future studies. The possibility exists that two or more compounds alone have tested to be non-toxic, but when present in a mixture, they may have a potentiating or synergist effect. Additional research is needed to identify appropriate model systems to study DNT effects which will improve the translation from alternative to human model systems. Also, additional work is needed to identify and develop accurate biomarkers which will signal exposure to DNT compounds early in the exposure period, facilitating medical intervention.
Professor David R. Wallace
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- animal models
- in vitro testing
- risk assessment
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Developmental Neurotoxicity Considerations in the Early Postnatal Period
Authors: April Neal Kluever
Abstract: In humans, neuronal differentiation, myelination, and migration are all incomplete at birth and may not fully develop until the third decade after birth. In addition to brain structural development, significant milestones in human behavioral development occur during the first 6 months of life, such as improved memory for past events, reduction of endogenous smiling, and disappearance of primary neonatal reflexes. The complexity and importance of the processes to the maturation of the human brain makes the early postnatal period susceptible to the effects of certain neurotoxins. For example, chemicals that disrupt synapse formation or activity (such as lead, ethanol, and manganese) or neuron migration (such as methyl mercury) may cause lasting defects in cognition and behavior.
Last update: 19 December 2013