Special Issue "Single Biomolecule Detection"


A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (15 August 2014)

Special Issue Editor

Guest Editor
Prof. Dr. Masateru Taniguchi

The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan
Website: http://www.bionano.sanken.osaka-u.ac.jp/
Phone: +81-6-6879-8445
Fax: +81-6-6875-2440
Interests: single molecular science; single molecular devices; nanofabrications

Special Issue Information

Dear Colleagues,

Single-biomolecule detection technologies with high throughput and high accuracy can provide new information in the fields of medical science and biology, and they are expected to be utilized as innovative technologies in the future development of medical treatments and drugs. An ideal single-biomolecule detection technology can identify targeted biomolecules and analyze blood and spittle containing specific biomolecules using an integrated chip, where pretreatment devices exclude all molecules except targeted molecules and after-treatment devices identify and treat targeted molecules. For example, using an integrated chip composed of MEMS/NEMS and nanopores, DNA molecules are separated/extracted from blood and sequenced by MEMS/NEMS and nanopore devices, respectively. However, pretreatment and after-treatment devices are developed individually in different fields, and there are few integrated devices that facilitate both pretreatment and after-treatment processes. Integration is a big barrier for practical single-biomolecule detection technologies.

The aim of this special issue is to furnish an opportunity to break through the barrier and discover innovative single-biomolecule detection technologies. Therefore, the papers include a wide range of studies regarding pretreatment, after-treatment, and integration devices, including MEMS, NEMS, fluid devices, nanopore devices, and single-molecule optical and electrical detection technologies.

Both review articles and original research papers relating to pretreatment and after-treatment devices are solicited. There is particular interest in papers concerning technologies where optical, electrical, and magnetic detections are performed using pretreatment and after-treatment devices fabricated by microfabrication technologies in order to focus on practical applications of single-biomolecule detection technologies using integrated devices.

Prof. Dr. Masateru Taniguchi
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).


  • Single biomolecules
  • Nanopore
  • Pretreatment devices
  • After-treatment devices

Related Special Issue

Published Papers (5 papers)

Download All Papers
Sort by:
Display options:
Select articles Export citation of selected articles as:
Select/unselect all
Displaying article 1-5
p. 19329-19335
by , , , ,  and
Sensors 2014, 14(10), 19329-19335; doi:10.3390/s141019329
Received: 25 August 2014 / Revised: 30 September 2014 / Accepted: 8 October 2014 / Published: 16 October 2014
Show/Hide Abstract | Cited by 5 | PDF Full-text (1756 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Single Biomolecule Detection)
abstract graphic
p. 6056-6083
by , , , , ,  and
Sensors 2014, 14(4), 6056-6083; doi:10.3390/s140406056
Received: 20 December 2013 / Revised: 10 March 2014 / Accepted: 21 March 2014 / Published: 27 March 2014
Show/Hide Abstract | Cited by 10 | PDF Full-text (1056 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Single Biomolecule Detection)
abstract graphic
p. 5174-5182
by , , , , , , ,  and
Sensors 2014, 14(3), 5174-5182; doi:10.3390/s140305174
Received: 9 December 2013 / Revised: 25 February 2014 / Accepted: 7 March 2014 / Published: 12 March 2014
Show/Hide Abstract | Cited by 1 | PDF Full-text (383 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Single Biomolecule Detection)
p. 2449-2467
by , , , ,  and
Sensors 2014, 14(2), 2449-2467; doi:10.3390/s140202449
Received: 14 December 2013 / Revised: 22 January 2014 / Accepted: 27 January 2014 / Published: 3 February 2014
Show/Hide Abstract | Cited by 3 | PDF Full-text (2667 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Single Biomolecule Detection)
p. 1195-1207
by , , , ,  and
Sensors 2014, 14(1), 1195-1207; doi:10.3390/s140101195
Received: 18 December 2013 / Revised: 3 January 2014 / Accepted: 7 January 2014 / Published: 10 January 2014
Show/Hide Abstract | Cited by 5 | PDF Full-text (370 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Single Biomolecule Detection)
Select/unselect all
Displaying article 1-5
Select articles Export citation of selected articles as:

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Site-Directed Synthesis of Freestanding Graphene Nano-Membrane Arrays
Pradeep Waduge, Joseph Larkin, Moneesh Upmanyu, Swastik Kar, and Meni Wanunu
Department of Physics, Northeastern University, 110 Forsyth St, Dana 111, Boston MA 02115, USA; E-Mail: wanunu@neu.edu
Freestanding graphene membranes are unique materials: the combination of atomically thin dimensions, remarkable mechanical robustness, and chemical stability, make porous graphene membrane devices attractive for various purification and detection applications. Nanopores in graphene and other 2D materials have been identified as promising devices for next-generation DNA sequencing, based on readout of either transverse DNA base-gated current or through-pore ion current. While several ground breaking studies of graphene-based nanopores for DNA analysis have been reported, all methods reported to date require a physical transfer of the graphene from its source of production onto an aperture support. The transfer process suffers from several drawbacks that include contamination, mechanical strain, and a low device throughput that arises from mechanical damage. In this work, we report a novel scalable approach for site-directed fabrication of pinhole-free graphene nano-membranes. Our approach yields high quality few-layer graphene membranes produced in less than a day on sub-micron apertures using a few steps. We highlight the functionality of these graphene devices by measuring DNA translocation through electron-beam fabricated nanopores in such membranes.

Last update: 7 August 2014

Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert