Special Issue "Single Biomolecule Detection"
Deadline for manuscript submissions: closed (15 August 2014)
Single-biomolecule detection technologies with high throughput and high accuracy can provide new information in the fields of medical science and biology, and they are expected to be utilized as innovative technologies in the future development of medical treatments and drugs. An ideal single-biomolecule detection technology can identify targeted biomolecules and analyze blood and spittle containing specific biomolecules using an integrated chip, where pretreatment devices exclude all molecules except targeted molecules and after-treatment devices identify and treat targeted molecules. For example, using an integrated chip composed of MEMS/NEMS and nanopores, DNA molecules are separated/extracted from blood and sequenced by MEMS/NEMS and nanopore devices, respectively. However, pretreatment and after-treatment devices are developed individually in different fields, and there are few integrated devices that facilitate both pretreatment and after-treatment processes. Integration is a big barrier for practical single-biomolecule detection technologies.
The aim of this special issue is to furnish an opportunity to break through the barrier and discover innovative single-biomolecule detection technologies. Therefore, the papers include a wide range of studies regarding pretreatment, after-treatment, and integration devices, including MEMS, NEMS, fluid devices, nanopore devices, and single-molecule optical and electrical detection technologies.
Both review articles and original research papers relating to pretreatment and after-treatment devices are solicited. There is particular interest in papers concerning technologies where optical, electrical, and magnetic detections are performed using pretreatment and after-treatment devices fabricated by microfabrication technologies in order to focus on practical applications of single-biomolecule detection technologies using integrated devices.
Prof. Dr. Masateru Taniguchi
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed Open Access monthly journal published by MDPI.
- Single biomolecules
- Pretreatment devices
- After-treatment devices
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Site-Directed Synthesis of Freestanding Graphene Nano-Membrane Arrays
Authors: Pradeep Waduge, Joseph Larkin, Moneesh Upmanyu, Swastik Kar, and Meni Wanunu
Affiliation: Department of Physics, Northeastern University, 110 Forsyth St, Dana 111, Boston MA 02115, USA; E-Mail: firstname.lastname@example.org
Abstract: Freestanding graphene membranes are unique materials: the combination of atomically thin dimensions, remarkable mechanical robustness, and chemical stability, make porous graphene membrane devices attractive for various purification and detection applications. Nanopores in graphene and other 2D materials have been identified as promising devices for next-generation DNA sequencing, based on readout of either transverse DNA base-gated current or through-pore ion current. While several ground breaking studies of graphene-based nanopores for DNA analysis have been reported, all methods reported to date require a physical transfer of the graphene from its source of production onto an aperture support. The transfer process suffers from several drawbacks that include contamination, mechanical strain, and a low device throughput that arises from mechanical damage. In this work, we report a novel scalable approach for site-directed fabrication of pinhole-free graphene nano-membranes. Our approach yields high quality few-layer graphene membranes produced in less than a day on sub-micron apertures using a few steps. We highlight the functionality of these graphene devices by measuring DNA translocation through electron-beam fabricated nanopores in such membranes.