Special Issue "Modeling and Analysis of Signal Transduction Networks"
A special issue of Processes (ISSN 2227-9717).
Deadline for manuscript submissions: closed (31 July 2014)
Prof. Dr. Juergen Hahn
Department of Biomedical Engineering, Department of Chemical & Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, New York, NY 12180, USA
Phone: +1 518 276 2138
Fax: +1 518 276 3035
Interests: systems biology; parameter estimation; experimental design; modeling
Signal transduction pathways play a key role in systems biology. These pathways are responsible for relaying cellular information and are also involved in regulating cellular responses. An understanding of signal transduction mechanisms may enable the improvement of treatment options for diseases that are affected by signal transduction mechanisms. One approach for elucidating the dynamics of signal transduction pathways is the derivation of models describing said pathways. However, deriving an accurate signal transduction pathway is difficult. The mechanisms tend to involve many components and there is cross-talk among different pathways. Also, measurements of signal transduction pathway components tend to be sparse and noisy such that the system will have a large degree of uncertainty with respect to both its structure and parameter values. Consequently, validating and refining signal transduction pathway models is crucial.
This Special Issue solicits contributions concerning the modeling and analysis of signal transduction pathways. Contributions involving the modeling and simulation of pathways are of interest. Also welcome are papers concerning methodologies used for modeling and analyzing pathways (e.g., sensitivity analysis, experimental design, parameter estimation, inverse problems or experimental techniques).
Professor Juergen Hahn
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- signal transduction
- sensitivity analysis
- parameter estimation
- experimental design