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Pharmaceutics
Special Issues
Polymeric Nanocapsules in Drug Delivery, Volume Ⅱ
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Polymeric Nanocapsules in Drug Delivery, Volume Ⅱ

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 1680

Special Issue Editors

Prof. Dr. Vanessa Carla Furtado Mosqueira

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Guest Editor
Department of Pharmacy - School of Pharmacy; Federal University of Ouro Preto, Ouro Preto, MG, Brazil
Interests: nanoparticles; formulations; treatment; drug delivery systems; nanotechnology; neglected diseases and cancer treatment
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Raquel Silva Araújo

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Guest Editor
College of Pharmacy, Department of Biological and Health Sciences, Federal University of Amapá, Rod. Juscelino Kubitschek, km 02 - Jardim Marco Zero, Macapá 68903-419, AP, Brazil
Interests: nanobiotechnology; pharmaceutical technology; nanocarriers; polymeric nanoparticles; natural products; radiopharmaceuticals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The development of nanostructured drug carriers has been the subject of intense research in the pharmaceutical field to optimize efficacy and reduce drug toxicity.

Polymeric nanocapsules (NCs) are widely used as drug nanocarriers for the delivery of diverse lipophilic molecules and some hydrophilic macromolecules. Nanocapsules are vesicular systems, containing in general a lipid-based core (liquid, semi-solid, or solid) surrounded by a polymeric wall. Their ability to modify the drug release and pharmacokinetic properties of active substances is associated with the size and chemical nature of the polymer. Many research projects have enabled the modification of nanocapsule surfaces, improving long-circulating properties, increasing immune stimulation, and particularly, decorating the surface with ligands such as small molecules, antibodies, peptides, and aptamers, with the aim to increase site-specific drug delivery.

Furthermore, nanocapsules have been demonstrating outstanding physicochemical characteristics, including biocompatibility, stability, and versatility as delivery systems to load a plethora of substances and macromolecules. NCs allow fine-tuning of the surface hydrophilicity, easy production, and scalability. All of these attributes contribute to making nanocapsules one of the most important and efficient drug delivery systems under consideration in the pharmaceutical area.

The scope of this Special Issue aims to cover the major features of polymeric nanocapsules systems in drug delivery including:

  • Processes of preparation
  • Characterization methods
  • Raw materials and physicochemistry
  • Surface modification
  • Drug release and delivery properties
  • Biodistribution
  • Efficacy studies
  • Their applicability for the diagnosis and therapeutics as nanomedicines for human and in the veterinary area
  • Technologies of nanocapsules drying
  • Scale-up technologies

Prof. Dr. Vanessa Carla Furtado Mosqueira
Prof. Dr. Raquel Silva Araújo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

19 pages, 4291 KiB  
Article
In Vitro Cytotoxicity and In Vivo Antitumor Activity of Lipid Nanocapsules Loaded with Novel Pyridine Derivatives
by Amr Selim Abu Lila, Mohammed Amran, Mohamed A. Tantawy, Ehssan H. Moglad, Shadeed Gad, Hadil Faris Alotaibi, Ahmad J. Obaidullah and El-Sayed Khafagy
Pharmaceutics 2023, 15(6), 1755; https://doi.org/10.3390/pharmaceutics15061755 - 16 Jun 2023
Cited by 1 | Viewed by 1297
Abstract
This study demonstrates high drug-loading of novel pyridine derivatives (S1–S4) in lipid- and polymer-based core–shell nanocapsules (LPNCs) for boosting the anticancer efficiency and alleviating toxicity of these novel pyridine derivatives. The nanocapsules were fabricated using a nanoprecipitation technique and characterized for particle size, [...] Read more.
This study demonstrates high drug-loading of novel pyridine derivatives (S1–S4) in lipid- and polymer-based core–shell nanocapsules (LPNCs) for boosting the anticancer efficiency and alleviating toxicity of these novel pyridine derivatives. The nanocapsules were fabricated using a nanoprecipitation technique and characterized for particle size, surface morphology, and entrapment efficiency. The prepared nanocapsules exhibited a particle size ranging from 185.0 ± 17.4 to 223.0 ± 15.3 nm and a drug entrapment of >90%. The microscopic evaluation demonstrated spherical-shaped nanocapsules with distinct core–shell structures. The in vitro release study depicted a biphasic and sustained release pattern of test compounds from the nanocapsules. In addition, it was obvious from the cytotoxicity studies that the nanocapsules showed superior cytotoxicity against both MCF-7 and A549 cancer cell lines, as manifested by a significant decrease in the IC50 value compared to free test compounds. The in vivo antitumor efficacy of the optimized nanocapsule formulation (S4-loaded LPNCs) was investigated in an Ehrlich ascites carcinoma (EAC) solid tumor-bearing mice model. Interestingly, the entrapment of the test compound (S4) within LPNCs remarkably triggered superior tumor growth inhibition when compared with either free S4 or the standard anticancer drug 5-fluorouracil. Such enhanced in vivo antitumor activity was accompanied by a remarkable increase in animal life span. Furthermore, the S4-loaded LPNC formulation was tolerated well by treated animals, as evidenced by the absence of any signs of acute toxicity or alterations in biochemical markers of liver and kidney functions. Collectively, our findings clearly underscore the therapeutic potential of S4-loaded LPNCs over free S4 in conquering EAC solid tumors, presumably via granting efficient delivery of adequate concentrations of the entrapped drug to the target site. Full article
(This article belongs to the Special Issue Polymeric Nanocapsules in Drug Delivery, Volume Ⅱ)
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