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Pharmaceutics
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Advances in Microneedle-Based Drug Delivery Systems Volume II
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Advances in Microneedle-Based Drug Delivery Systems Volume II

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 23186

Special Issue Editors

Prof. Dr. Hyungil Jung

E-Mail Website
Guest Editor
Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea
Interests: transdermal drug delivery; dissolving microneedle; microneedle applicator
Special Issues, Collections and Topics in MDPI journals
Dr. Huisuk Yang

E-Mail Website
Guest Editor
Juvic Inc., Seoul, Korea
Interests: drug delivery; transdermal delivery; polymer processing; micro-structures; diagnosis

Special Issue Information

Dear Colleagues,

Over the past few decades, transdermal drug delivery through microneedles has become an attractive approach for therapeutics compared with parenteral and oral routes. Microneedles are capable of overcoming the barrier properties of stratum corneum in a minimally invasive manner, increasing the delivery efficiency and effectiveness of encapsulated compounds across the skin. The number of publications related to microneedles has been rapidly increasing. Moreover, to overcome the limitations of previously developed technologies, a series of novel microneedle fabrication methods, applicators, and novel geometries were introduced. Therefore, in this Special Issue, we aim to further explore the potential of microneedles in the pharmaceutical field by showcasing the most recent advances in microneedle-based drug delivery systems.

Prof. Dr. Hyungil Jung
Dr. Huisuk Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microneedle technology
  • biodegradable polymer
  • transdermal delivery
  • biomaterial
  • applicators
  • microneedles in pharmaceuticals

Related Special Issue

Published Papers (5 papers)

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Research

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15 pages, 3121 KiB  
Article
Pharmacokinetic Evaluation of a Novel Donepezil-Loaded Dissolving Microneedle Patch in Rats
by Naveed Ur Rehman, Chanwoo Song, Junhyeong Kim, Inhwan Noh, Yun-Seok Rhee and Hye Jin Chung
Pharmaceutics 2022, 14(1), 5; https://doi.org/10.3390/pharmaceutics14010005 - 21 Dec 2021
Cited by 8 | Viewed by 4016
Abstract
Research on the development of dissolving microneedles (DMNs) has focused on bolus drug delivery, with little attention on sustained release. Here, we evaluated the sustained release, absorption pattern, and effective drug permeation of a novel donepezil-loaded DMN patch through an in vivo investigation [...] Read more.
Research on the development of dissolving microneedles (DMNs) has focused on bolus drug delivery, with little attention on sustained release. Here, we evaluated the sustained release, absorption pattern, and effective drug permeation of a novel donepezil-loaded DMN patch through an in vivo investigation on rats. The applications of DMN patches to the shaved skin of rats for 1 week and 1 h were compared with oral donepezil administration to assess their sustained release capabilities. We used a validated liquid chromatography–tandem mass spectrometry method to quantify donepezil in the plasma. We found that the microneedle arrays effectively delivered donepezil across the skin, with dissolution observed within 1 h of application. Furthermore, skin irritation test showed that the patches produced no irritation response. The DMN arrays also effectively increased drug permeation and demonstrated sustained release and absorption of donepezil from DMN patches. These patches allow extended dosing intervals, reduced gastrointestinal adverse effects, and convenient self-administration to mitigate poor drug compliance, making them beneficial for the treatment of elderly patients with Alzheimer’s disease. Full article
(This article belongs to the Special Issue Advances in Microneedle-Based Drug Delivery Systems Volume II)
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18 pages, 3862 KiB  
Article
Assessment and Modeling of Plasmonic Photothermal Therapy Delivered via a Fiberoptic Microneedle Device Ex Vivo
by Forhad Akhter, Santiago Manrique-Bedoya, Chris Moreau, Andrea Lynn Smith, Yusheng Feng, Kathryn M. Mayer and R. Lyle Hood
Pharmaceutics 2021, 13(12), 2133; https://doi.org/10.3390/pharmaceutics13122133 - 10 Dec 2021
Cited by 4 | Viewed by 2900
Abstract
Plasmonic photothermal therapy (PPTT) has potential as a superior treatment method for pancreatic cancer, a disease with high mortality partially attributable to the currently non-selective treatment options. PPTT utilizes gold nanoparticles infused into a targeted tissue volume and exposed to a specific light [...] Read more.
Plasmonic photothermal therapy (PPTT) has potential as a superior treatment method for pancreatic cancer, a disease with high mortality partially attributable to the currently non-selective treatment options. PPTT utilizes gold nanoparticles infused into a targeted tissue volume and exposed to a specific light wavelength to induce selective hyperthermia. The current study focuses on developing this approach within an ex vivo porcine pancreas model via an innovative fiberoptic microneedle device (FMD) for co-delivering light and gold nanoparticles. The effects of laser wavelengths (808 vs. 1064 nm), irradiances (20–50 mW·mm−2), and gold nanorod (GNR) concentrations (0.1–3 nM) on tissue temperature profiles were evaluated to assess and control hyperthermic generation. The GNRs had a peak absorbance at ~800 nm. Results showed that, at 808 nm, photon absorption and subsequent heat generation within tissue without GNRs was 65% less than 1064 nm. The combination of GNRs and 808 nm resulted in a 200% higher temperature rise than the 1064 nm under similar conditions. A computational model was developed to predict the temperature shift and was validated against experimental results with a deviation of <5%. These results show promise for both a predictive model and spatially selective, tunable treatment modality for pancreatic cancer. Full article
(This article belongs to the Special Issue Advances in Microneedle-Based Drug Delivery Systems Volume II)
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17 pages, 3714 KiB  
Article
Optimization of Layered Dissolving Microneedle for Sustained Drug Delivery Using Heat-Melted Poly(Lactic-Co-glycolic Acid)
by Chisong Lee, Jinkyung Kim, Daniel Junmin Um, Youseong Kim, Hye Su Min, Jiwoo Shin, Jee Hye Nam, Geonwoo Kang, Mingyu Jang, Huisuk Yang and Hyungil Jung
Pharmaceutics 2021, 13(7), 1058; https://doi.org/10.3390/pharmaceutics13071058 - 10 Jul 2021
Cited by 10 | Viewed by 3281
Abstract
Dissolving microneedles (DMNs) have been used as an alternative drug delivery system to deliver therapeutics across the skin barrier in a painless manner. In this study, we propose a novel heat-melting method for the fabrication of hydrophobic poly(lactic-co-glycolic acid) (PLGA) DMNs, without the [...] Read more.
Dissolving microneedles (DMNs) have been used as an alternative drug delivery system to deliver therapeutics across the skin barrier in a painless manner. In this study, we propose a novel heat-melting method for the fabrication of hydrophobic poly(lactic-co-glycolic acid) (PLGA) DMNs, without the use of potentially harmful organic solvents. The drug-loaded PLGA mixture, which consisted of a middle layer of the DMN, was optimized and successfully implanted into ex vivo porcine skin. Implanted HMP-DMNs separated from the patch within 10 min, enhancing user compliance, and the encapsulated molecules were released for nearly 4 weeks thereafter. In conclusion, the geometry of HMP-DMNs was successfully optimized for safe and effective transdermal sustained drug delivery without the use of organic solvents. This study provides a strategy for the innovative utilization of PLGA as a material for transdermal drug delivery systems. Full article
(This article belongs to the Special Issue Advances in Microneedle-Based Drug Delivery Systems Volume II)
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Review

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45 pages, 5690 KiB  
Review
Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges
by Prateek Ranjan Yadav, Monika Nasrin Munni, Lauryn Campbell, Golam Mostofa, Lewis Dobson, Morayo Shittu, Sudip Kumar Pattanayek, Md. Jasim Uddin and Diganta Bhusan Das
Pharmaceutics 2021, 13(8), 1132; https://doi.org/10.3390/pharmaceutics13081132 - 24 Jul 2021
Cited by 32 | Viewed by 6329
Abstract
The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric [...] Read more.
The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the translation of MNs from laboratory to clinical practice. The review reveals that polymers are most appropriately used for dissolvable and swellable MNs due to their wide range of tunable properties and that natural polymers are an ideal material choice as they structurally mimic native cellular environments. It has also been concluded that natural and synthetic polymer combinations are useful as polymers usually lack mechanical strength, stability, or other desired properties for the fabrication and insertion of MNs. This review evaluates fabrication methods and materials choice, disease and health conditions, clinical challenges, and the future of MNs in public healthcare services, focusing on literature from the last decade. Full article
(This article belongs to the Special Issue Advances in Microneedle-Based Drug Delivery Systems Volume II)
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37 pages, 3769 KiB  
Review
3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery
by Merima Sirbubalo, Amina Tucak, Kenan Muhamedagic, Lamija Hindija, Ognjenka Rahić, Jasmina Hadžiabdić, Ahmet Cekic, Derzija Begic-Hajdarevic, Maida Cohodar Husic, Almir Dervišević and Edina Vranić
Pharmaceutics 2021, 13(7), 924; https://doi.org/10.3390/pharmaceutics13070924 - 22 Jun 2021
Cited by 18 | Viewed by 5580
Abstract
Microneedles (MNs) represent the concept of attractive, minimally invasive puncture devices of micron-sized dimensions that penetrate the skin painlessly and thus facilitate the transdermal administration of a wide range of active substances. MNs have been manufactured by a variety of production technologies, from [...] Read more.
Microneedles (MNs) represent the concept of attractive, minimally invasive puncture devices of micron-sized dimensions that penetrate the skin painlessly and thus facilitate the transdermal administration of a wide range of active substances. MNs have been manufactured by a variety of production technologies, from a range of materials, but most of these manufacturing methods are time-consuming and expensive for screening new designs and making any modifications. Additive manufacturing (AM) has become one of the most revolutionary tools in the pharmaceutical field, with its unique ability to manufacture personalized dosage forms and patient-specific medical devices such as MNs. This review aims to summarize various 3D printing technologies that can produce MNs from digital models in a single step, including a survey on their benefits and drawbacks. In addition, this paper highlights current research in the field of 3D printed MN-assisted transdermal drug delivery systems and analyzes parameters affecting the mechanical properties of 3D printed MNs. The current regulatory framework associated with 3D printed MNs as well as different methods for the analysis and evaluation of 3D printed MN properties are outlined. Full article
(This article belongs to the Special Issue Advances in Microneedle-Based Drug Delivery Systems Volume II)
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