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Pharmaceutics
Special Issues
The Effect of Gastrectomy on Drug Activity
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The Effect of Gastrectomy on Drug Activity

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 7505

Special Issue Editors

Dr. Marta Karaźniewicz-Łada

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Guest Editor
Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781 Poznań, Poland
Interests: bioanalysis; HPLC-MS/MS technique; method validation; pharmacokinetics; pharmacogenetics
Special Issues, Collections and Topics in MDPI journals
Dr. Agnieszka Karbownik

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Guest Editor
Department of Clinical Pharmacy and Biopharmacy, Poznan University of Medical Sciences, 14 Św. Marii Magdaleny Str., 61-861 Poznan, Poland
Interests: pharmacokinetics; drug-drug interaction; tyrosine kinase inhibitor; blood-brain barrier
Prof. Dr. Edyta Szałek

E-Mail Website
Guest Editor
Department of Clinical Pharmacy and Biopharmacy, Poznan University of Medical Sciences, 14 Św. Marii Magdaleny Str., 61-861 Poznan, Poland
Interests: clinical pharmacy; biopharmacy

Special Issue Information

Dear Colleagues,

Complete or partial gastric resection significantly changes gastrointestinal motility. The absorption area and the pH of the gastric juice are reduced, enzymes and transporters are disturbed, and the duodenum becomes a non-functional organ. All these anatomical and physiological changes in the gastrointestinal tract affect the absorption, metabolism, and transport of drugs taken orally.

For this Special Issue, we welcome contributions on every aspect of total or partial gastric resection in obese or cancer patients. Of interest are the pharmacokinetics of drugs, mainly the absorption and metabolism of anti-cancer drugs, as well as therapeutic drug monitoring. An additional aspect that can be discussed is the influence of gender, age, obesity, or diabetes on drug activity after gastrectomy.

Dr. Marta Karaźniewicz-Łada
Dr. Agnieszka Karbownik
Prof. Dr. Edyta Szałek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastrectomy
  • pharmacokinetics
  • absorption
  • gastric emptying
  • drug therapy, combination

Published Papers (2 papers)

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14 pages, 2134 KiB  
Article
Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin
by Arik Dahan, Daniel Porat, Milica Markovic, Moran Zur, Olga Kister and Peter Langguth
Pharmaceutics 2021, 13(11), 1873; https://doi.org/10.3390/pharmaceutics13111873 - 5 Nov 2021
Cited by 7 | Viewed by 2057
Abstract
Bariatric surgery is an effective treatment for severe obesity and related comorbidities, such as type II diabetes. Gastric bypass surgery shortens the length of the intestine, possibly leading to altered drug absorption. Metformin, a first-line treatment for type II diabetes, has permeability-dependent drug [...] Read more.
Bariatric surgery is an effective treatment for severe obesity and related comorbidities, such as type II diabetes. Gastric bypass surgery shortens the length of the intestine, possibly leading to altered drug absorption. Metformin, a first-line treatment for type II diabetes, has permeability-dependent drug absorption, which may be sensitive to intestinal anatomic changes during bypass surgery, including Roux-en-Y gastric bypass (RYGB). Previous computer simulation data indicate increased metformin absorption after RYGB. In this study, we experimentally determined the region-dependent permeability of metformin, using the rat single-pass intestinal perfusion method (SPIP), which we then implemented into GastroPlusTM to assess the contribution of our SPIP data to post-RYGB metformin absorption modeling. Previous simulations allowed a good fit with in vivo literature data on healthy and obese control subjects. However, it was revealed that for post-RYGB drug absorption predictions, simply excluding the duodenum/jejunum is insufficient, as the software underestimates the observed plasma concentrations post-RYGB. By implementing experimentally determined segmental-dependent permeabilities for metformin in the remaining segments post-surgery, GastroPlusTM proved to fit the observed plasma concentration profile, making it a useful tool for predicting drug absorption after gastric bypass. Reliable evaluation of the parameters dictating drug absorption is required for the accurate prediction of overall absorption after bariatric surgery. Full article
(This article belongs to the Special Issue The Effect of Gastrectomy on Drug Activity)
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Review

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19 pages, 1761 KiB  
Review
The Effects of Bariatric Surgery and Gastrectomy on the Absorption of Drugs, Vitamins, and Mineral Elements
by Miłosz Miedziaszczyk, Patrycja Ciabach and Edyta Szałek
Pharmaceutics 2021, 13(12), 2111; https://doi.org/10.3390/pharmaceutics13122111 - 7 Dec 2021
Cited by 12 | Viewed by 4733
Abstract
Bariatric surgery, which is an effective treatment for obesity, and gastrectomy, which is the primary treatment method for gastric cancer, alter the anatomy and physiology of the digestive system. Weight loss and changes in the gastrointestinal tract may affect the pharmacokinetic parameters of [...] Read more.
Bariatric surgery, which is an effective treatment for obesity, and gastrectomy, which is the primary treatment method for gastric cancer, alter the anatomy and physiology of the digestive system. Weight loss and changes in the gastrointestinal tract may affect the pharmacokinetic parameters of oral medications. Both bariatric and cancer patients use drugs chronically or temporarily. It is important to know how surgery affects their pharmacokinetics to ensure an effective and safe therapy. The Cochrane, PubMed, and Scopus databases were searched independently by two authors. The search strategy included controlled vocabulary and keywords. Studies show that bariatric surgery and gastrectomy most often reduce the time to maximum plasma concentration (tmax) and decrease the maximum plasma concentration (Cmax) in comparison with the values of these parameters measured in healthy volunteers. Vitamin and mineral deficiencies are also observed. The effect depends on the type of surgery and the properties of the drug. It is recommended to use the drugs that have been tested on these groups of patients as it is possible to monitor them. Full article
(This article belongs to the Special Issue The Effect of Gastrectomy on Drug Activity)
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