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Pharmaceutics
Special Issues
Nanoparticles for Local Drug Delivery
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Nanoparticles for Local Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 3131

Special Issue Editors

Prof. Dr. Snezana Savic

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Guest Editor
Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Interests: nanoplatforms for brain and skin delivery; innovative biocompatible excipients; poorly water-soluble drugs; physicochemical/in vitro/in silico characterization methods; in vivo pharmacokinetics in rats
Special Issues, Collections and Topics in MDPI journals
Dr. Tanja Ilić

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Guest Editor
Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia
Interests: lipid nanosystems for localized drug delivery (brain, skin); formulation development; physicochemical characterization methods; in vitro drug permeation through biological barriers (blood–brain barrier, skin); in vivo (dermo) pharmacokinetics
Dr. Sanela Savic

E-Mail Website
Guest Editor
Faculty of Technology in Leskovac, University of Niš, Bulevar Oslobodjenja 124, 16000 Leskovac, Serbia
Interests: lipid nanosystems; experimental design; brain targeting; in vivo pharmacokinetics; skin delivery; skin bioengineering techniques; safety and efficacy testing

Special Issue Information

Dear Colleagues,

Despite increasing advances in the design and development of modern drug delivery systems and technologies, the effective treatment of many diseases/disorders such as cancer, neurodegenerative and neuromuscular disorders, inflammatory diseases and infections (to name a few) still remains a major challenge due to the presence of restrictive biological barriers (such as the mucosal epithelium in the intestine, lungs, nose and mouth, skin, blood–brain barrier, blood–retinal barrier). To deliver a sufficient therapeutic concentration of a drug at the intended site of action (diseased organ/tissue/target cells) in a predictable/controlled manner, thereby avoiding/reducing off-site toxicity and systemic adverse effects, local drug delivery strategies have been established as a promising approach. Recently, significant progress has been made in the field of local drug delivery, achieved either through local or systemic administration (targeted/triggered approach), largely due to the implementation of nanoparticles. Although diverse types of nanoparticles (lipid-based, polymeric, metallic, carbon nanotubes, dendrimers, etc.) have been developed for local/targeted/triggered delivery of various therapeutics (anticancer drugs, central nervous system drugs, anti-inflammatory drugs, antimicrobial agents, hormones, nucleic acids, etc.) via different routes of administration (e.g., intratumoral, intra-articular, (intra)nasal, (intra)ocular, (trans)dermal, (intra)oral, oromucosal, sublingual, dental, pulmonary/inhalation, vaginal/uterine, etc.), additional efforts are required to optimize drug incorporation and release, formulation stability and shelf-life, biocompatibility, safety, biodistribution and targeting, giving this topic permanent and growing interest.

We warmly invite researchers to share their ideas, insights and perspectives from the dynamic landscape of nanoparticles for local drug delivery, covering a wide range of topics related to the following areas, among others: formulation and optimization of drug-containing nanoparticles, passive/active targeting and triggering approaches for site-specific or site-avoidance drug delivery, controlled release mechanisms and kinetics, in vitro/in vivo fate and interactions with the biological environment, biocompatibility and safety assessments, clinical applications and translational research.

Prof. Dr. Snezana Savic
Dr. Tanja Ilić
Dr. Sanela Savic
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipid nanoparticles
  • polymeric nanoparticles
  • inorganic nanoparticles
  • localized administration routes
  • targeted/triggered drug delivery
  • critical quality attributes
  • biocompatibility
  • clinical application and translation

Published Papers (2 papers)

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Research

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27 pages, 4694 KiB  
Article
Thermosensitive Polymeric Nanoparticles for Drug Co-Encapsulation and Breast Cancer Treatment
by Vanessa Franco Carvalho Dartora, Julia S. Passos, Leticia V. Costa-Lotufo, Luciana B. Lopes and Alyssa Panitch
Pharmaceutics 2024, 16(2), 231; https://doi.org/10.3390/pharmaceutics16020231 - 5 Feb 2024
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Abstract
Despite advances in breast cancer treatment, there remains a need for local management of noninvasive, low-grade ductal carcinoma in situ (DCIS). These focal lesions are well suited for local intraductal treatment. Intraductal administration supported target site drug retention, improved efficacy, and reduced systemic [...] Read more.
Despite advances in breast cancer treatment, there remains a need for local management of noninvasive, low-grade ductal carcinoma in situ (DCIS). These focal lesions are well suited for local intraductal treatment. Intraductal administration supported target site drug retention, improved efficacy, and reduced systemic exposure. Here, we used a poly(N-isopropyl acrylamide, pNIPAM) nanoparticle delivery system loaded with cytotoxic piplartine and an MAPKAP Kinase 2 inhibitor (YARA) for this purpose. For tumor environment targeting, a collagen-binding peptide SILY (RRANAALKAGELYKSILYGSG-hydrazide) was attached to pNIPAM nanoparticles, and the nanoparticle diameter, zeta potential, drug loading, and release were assessed. The system was evaluated for cytotoxicity in a 2D cell culture and 3D spheroids. In vivo efficacy was evaluated using a chemical carcinogenesis model in female Sprague–Dawley rats. Nanoparticle delivery significantly reduced the IC50 of piplartine (4.9 times) compared to the drug in solution. The combination of piplartine and YARA in nanoparticles further reduced the piplartine IC50 (~15 times). Treatment with these nanoparticles decreased the in vivo tumor incidence (5.2 times). Notably, the concentration of piplartine in mammary glands treated with nanoparticles (35.3 ± 22.4 μg/mL) was substantially higher than in plasma (0.7 ± 0.05 μg/mL), demonstrating targeted drug retention. These results indicate that our nanocarrier system effectively reduced tumor development with low systemic exposure. Full article
(This article belongs to the Special Issue Nanoparticles for Local Drug Delivery)
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Review

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44 pages, 2418 KiB  
Review
Recent Approaches for the Topical Treatment of Psoriasis Using Nanoparticles
by Krisztina Bodnár, Pálma Fehér, Zoltán Ujhelyi, Ildikó Bácskay and Liza Józsa
Pharmaceutics 2024, 16(4), 449; https://doi.org/10.3390/pharmaceutics16040449 - 25 Mar 2024
Viewed by 1411
Abstract
Psoriasis (PSO) is a chronic autoimmune skin condition characterized by the rapid and excessive growth of skin cells, which leads to the formation of thick, red, and scaly patches on the surface of the skin. These patches can be itchy and painful, and [...] Read more.
Psoriasis (PSO) is a chronic autoimmune skin condition characterized by the rapid and excessive growth of skin cells, which leads to the formation of thick, red, and scaly patches on the surface of the skin. These patches can be itchy and painful, and they may cause discomfort for patients affected by this condition. Therapies for psoriasis aim to alleviate symptoms, reduce inflammation, and slow down the excessive skin cell growth. Conventional topical treatment options are non-specific, have low efficacy and are associated with adverse effects, which is why researchers are investigating different delivery mechanisms. A novel approach to drug delivery using nanoparticles (NPs) shows promise in reducing toxicity and improving therapeutic efficacy. The unique properties of NPs, such as their small size and large surface area, make them attractive for targeted drug delivery, enhanced drug stability, and controlled release. In the context of PSO, NPs can be designed to deliver active ingredients with anti-inflammatory effect, immunosuppressants, or other therapeutic compounds directly to affected skin areas. These novel formulations offer improved access to the epidermis and facilitate better absorption, thus enhancing the therapeutic efficacy of conventional anti-psoriatic drugs. NPs increase the surface-to-volume ratio, resulting in enhanced penetration through the skin, including intracellular, intercellular, and trans-appendage routes. The present review aims to discuss the latest approaches for the topical therapy of PSO using NPs. It is intended to summarize the results of the in vitro and in vivo examinations carried out in the last few years regarding the effectiveness and safety of nanoparticles. Full article
(This article belongs to the Special Issue Nanoparticles for Local Drug Delivery)
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