Targeted Drug Delivery Systems for Treating Gastrointestinal Inflammatory Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: closed (10 November 2021) | Viewed by 4411

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Guest Editor
College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea
Interests: nanomedicine; colon-targeted delivery; wound healing; nitric oxide delivery; infectious diseases
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Special Issue Information

The gastrointestinal tract (GIT), which includes all the digestive systems extending from the mouth to the anus, is often vulnerable to inflammation. Gastrointestinal inflammatory diseases including periodontitis, gastric ulcer, gastritis, Crohn’s disease, and ulcerative colitis are significant sources of disease-associated morbidity and mortality as well as pain and disability worldwide. However, most of the drugs which are currently used to treat gastrointestinal inflammatory diseases do not selectively target the region where inflammation occurs, thus leading to frequent dosing and potential adverse effects which can negatively affect patient compliance. In this sense, there is an urgent need for innovative delivery systems that deliver a drug to the site of inflammation, prolong local drug availability, improve therapeutic efficacy, and reduce drug side effects.

This Special Issue of Pharmaceutics highlights the recent progress of targeted delivery systems that can effectively treat gastrointestinal inflammatory diseases. Any innovative systems that deliver a therapeutic agent to inflammatory regions in the GIT will be welcome.

Prof. Dr. Jin-Wook Yoo
Guest Editor

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Keywords

  • gastrointestinal inflammation
  • targeted delivery systems
  • Crohn’s disease
  • ulcerative colitis
  • gastric ulcer
  • gastritis
  • periodontitis

Published Papers (1 paper)

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Research

15 pages, 6411 KiB  
Article
pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A Crystals to Treat Ulcerative Colitis
by Murtada A. Oshi, Juho Lee, Jihyun Kim, Nurhasni Hasan, Eunok Im, Yunjin Jung and Jin-Wook Yoo
Pharmaceutics 2021, 13(9), 1412; https://doi.org/10.3390/pharmaceutics13091412 - 6 Sep 2021
Cited by 18 | Viewed by 3623
Abstract
Cyclosporine A (CsA) is a potent immunosuppressant for treating ulcerative colitis (UC). However, owing to severe systemic side effects, CsA application in UC therapy remains limited. Herein, a colon-targeted drug delivery system consisting of CsA crystals (CsAc)-loaded, Eudragit S 100 (ES)-coated alginate microparticles [...] Read more.
Cyclosporine A (CsA) is a potent immunosuppressant for treating ulcerative colitis (UC). However, owing to severe systemic side effects, CsA application in UC therapy remains limited. Herein, a colon-targeted drug delivery system consisting of CsA crystals (CsAc)-loaded, Eudragit S 100 (ES)-coated alginate microparticles (CsAc-EAMPs) was established to minimize systemic side effects and enhance the therapeutic efficacy of CsA. Homogeneously-sized CsAs (3.1 ± 0.9 μm) were prepared by anti-solvent precipitation, followed by the fabrication of 47.1 ± 6.5 μm-sized CsAc-EAMPs via ionic gelation and ES coating. CsAc-EAMPs exhibited a high drug loading capacity (48 ± 5%) and a CsA encapsulation efficacy of 77 ± 9%. The in vitro drug release study revealed that CsA release from CsAc-EAMPs was suppressed under conditions simulating the stomach and small intestine, resulting in minimized systemic absorption and side effects. Following exposure to the simulated colon conditions, along with ES dissolution and disintegration of alginate microparticles, CsA was released from CsAc-EAMPs, exhibiting a sustained-release profile for up to 24 h after administration. Given the effective colonic delivery of CsA molecules, CsAc-EAMPs conferred enhanced anti-inflammatory activity in mouse model of dextran sulfate sodium (DSS)-induced colitis. These findings suggest that CsAc-EAMPs is a promising drug delivery system for treating UC. Full article
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