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Pharmaceutics
Special Issues
Hydrogel Systems for Efficient Drug Delivery
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Hydrogel Systems for Efficient Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 10 June 2024 | Viewed by 1749

Special Issue Editors

Dr. Vesna V. Panić

E-Mail Website
Guest Editor
Innovation Center of Faculty of Technology and Metallurgy, The University of Belgrade, 4 Karnegijeva Street, 11000 Belgrade, Serbia
Interests: hydrogel; drug delivery system; hydrogel composites; controlled delivery; targeted delivery; drug loading; drug release kinetics; degradation; administration routes; oral delivery; transdermal delivery; in vitro and in vivo analysis
Prof. Dr. Rada Pjanović

E-Mail Website
Guest Editor
Department of Chemical Engineering, Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11 000 Belgrade, Serbia
Interests: hydrogel; drug delivery system; hydrogel composites; controlled delivery; targeted delivery; drug loading; drug release kinetics; degradation; administration routes; oral delivery; transdermal delivery; in vitro and in vivo analysis
Dr. Maja Marković

E-Mail Website
Guest Editor
Innovation Center of Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia
Interests: hydrogel; drug delivery system; hydrogel composites; controlled delivery; targeted delivery; drug loading; drug release kinetics; degradation; administration routes; oral delivery; transdermal delivery; in vitro and in vivo analysis

Special Issue Information

Dear Colleagues,

Hydrogels have shown significance in a wide variety of fields and attained the long-term interest of the research community; thus, we are pleased to announce the Special Issue named "Hydrogel Systems for Efficient Drug Delivery".

The aim of this Special Issue is to present valuable achievements in up-to-date drug delivery systems (DDS) based on hydrogels. Particular focus will be put on the science and technology behind the carrier and overall DDS design, and their application. The Special Issue will cover all innovative aspects of all kinds of polymeric hydrogels, multi-functional and stimuli-responsive hydrogels, composite hydrogels, and hybrid hydrogels used in buccal, oral, nasal, ocular, pulmonary, transdermal, vaginal, and gastrointestinal applications, among other drug delivery systems. Papers providing new aspects of the overall hydrogel behavior during drug loading or delivery, the monitoring of the pharmacokinetics and controlled delivery, as well as preclinical data, are preferable. The release of diverse active substances (drugs, vitamins, enzymes, DNK, RNK, phyto therapeutics, proteins, etc.) and the comparison of the release efficiency with previously reported systems/results are welcomed.

We hope that this Special Issue will attract a wider readership and become a valuable resource for scientists working toward the further development of pharmaceutics and hydrogel sciences. It is our pleasure to invite you to take part in this Special Issue and submit your work (full papers and reviews).

Dr. Vesna V. Panić
Prof. Dr. Rada Pjanović
Dr. Maja Marković
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogel
  • drug delivery system
  • hydrogel composites
  • controlled delivery
  • targeted delivery
  • drug loading
  • drug release kinetics
  • degradation
  • administration routes
  • oral delivery
  • transdermal delivery
  • in vitro and in vivo analyses

Published Papers (1 paper)

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Research

26 pages, 4744 KiB  
Article
Tailoring Risperidone-Loaded Glycethosomal In Situ Gels Using Box–Behnken Design for Treatment of Schizophrenia-Induced Rats via Intranasal Route
by Marwa H. Abdallah, Hemat El-Sayed El-Horany, Hanan M. El-Nahas and Tarek M. Ibrahim
Pharmaceutics 2023, 15(11), 2521; https://doi.org/10.3390/pharmaceutics15112521 - 24 Oct 2023
Cited by 1 | Viewed by 1056
Abstract
Schizophrenic patients often face challenges with adherence to oral regimens. The study aimed to highlight the potentiality of intranasal ethanol/glycerin-containing lipid-nanovesicles (glycethosomes) incorporated into in situ gels for sustaining anti-psychotic risperidone (RS) release. The Box–Behnken Design (BBD) was followed for in vitro characterization. [...] Read more.
Schizophrenic patients often face challenges with adherence to oral regimens. The study aimed to highlight the potentiality of intranasal ethanol/glycerin-containing lipid-nanovesicles (glycethosomes) incorporated into in situ gels for sustaining anti-psychotic risperidone (RS) release. The Box–Behnken Design (BBD) was followed for in vitro characterization. Glycethosomal-based in situ gels were examined by physical, ex vivo, and in vivo investigations. The ethanol impact on minimizing the vesicle size (VS) and enhancing the zeta potential (ZP) and entrapment efficiency (EE%) of nanovesicles was observed. Glycerin displayed positive action on increasing VS and ZP of nanovesicles, but reduced their EE%. After incorporation into various mucoadhesive agent-enriched poloxamer 407 (P407) in situ gels, the optimized gel containing 20% P407 and 1% hydroxypropyl methyl cellulose-K4M (HPMC-K4M) at a 4:1 gel/glycethosomes ratio showed low viscosity and high spreadability with acceptable pH, gel strength, and mucoadhesive strength ranges. The ethanol/glycerin mixture demonstrated a desirable ex vivo skin permeability of RS through the nasal mucosa. By pharmacokinetic analysis, the optimized gel showed eight-fold and three-fold greater increases in RS bioavailability than the control gel and marketed tablet, respectively. Following biochemical assessments of schizophrenia-induced rats, the optimized gel boosted the neuroprotective, anti-oxidant, and anti-inflammatory action of RS in comparison to other tested preparations. Collectively, the intranasal RS-loaded glycethosomal gel offered a potential substitute to oral therapy for schizophrenic patients. Full article
(This article belongs to the Special Issue Hydrogel Systems for Efficient Drug Delivery)
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