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Pharmaceutics
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Challenges and Innovative Solutions in Nasal Drug Delivery: From Formulation...
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Challenges and Innovative Solutions in Nasal Drug Delivery: From Formulation Development to Mode of Administration, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 504

Special Issue Editor

Prof. Dr. Anita Hafner

E-Mail Website
Guest Editor
Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, 10000 Zagreb, Croatia
Interests: nasal drug delivery; nasal powders; spray-drying; nanoparticles; in situ gelling systems; nasal deposition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nasal drug administration offers a wide range of therapeutic options, including local and systemic drug delivery, brain-targeted therapy and mucosal vaccination. However, its potential has yet to be fully exploited. Widening the palette of nasally administered drugs requires the development of innovative drug formulations enhancing drug availability at the action site. Namely, formulation strategy is the key to solving drug solubility, permeation and stability issues as well as improving mucoadhesive performance. Another key aspect is the consideration of efficient drug deposition in specific nasal regions of interest, which is a prerequisite for effective nasal therapy.

This Special Issue aims to highlight the latest strategies and innovations in the development and administration of nasal drug delivery systems. We are pleased to invite you to submit your original research articles or reviews within this subject area. Research topics of interest include (but are not limited to) the following: development of innovative liquid and powder nasal drug delivery systems; nanotechnology in nasal drug delivery; in vitro/ex vivo/in vivo characterization methods in nasal formulation development; and nasal deposition studies.

I look forward to receiving your contributions.

Prof. Dr. Anita Hafner
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • innovative nasal drug formulations
  • local effect
  • systemic bioavailability
  • nose-to-brain delivery
  • mucoadhesion
  • biocompatibility
  • permeability
  • nasal deposition
  • nasal delivery device

Published Papers (1 paper)

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Research

22 pages, 5653 KiB  
Article
Effects of Nozzle Retraction Elimination on Spray Distribution in Middle-Posterior Turbinate Regions: A Comparative Study
by Amr Seifelnasr, Xiuhua Si and Jinxiang Xi
Pharmaceutics 2024, 16(5), 683; https://doi.org/10.3390/pharmaceutics16050683 - 19 May 2024
Viewed by 255
Abstract
The standard multi-dose nasal spray pump features an integrated actuator and nozzle, which inevitably causes a retraction of the nozzle tip during application. The retraction stroke is around 5.5 mm and drastically reduces the nozzle’s insertion depth, which further affects the initial nasal [...] Read more.
The standard multi-dose nasal spray pump features an integrated actuator and nozzle, which inevitably causes a retraction of the nozzle tip during application. The retraction stroke is around 5.5 mm and drastically reduces the nozzle’s insertion depth, which further affects the initial nasal spray deposition and subsequent translocation, potentially increasing drug wastes and dosimetry variability. To address this issue, we designed a new spray pump that separated the nozzle from the actuator and connected them with a flexible tube, thereby eliminating nozzle retraction during application. The objective of this study is to test the new device’s performance in comparison to the conventional nasal pump in terms of spray generation, plume development, and dosimetry distribution. For both devices, the spray droplet size distribution was measured using a laser diffraction particle analyzer. Plume development was recorded with a high-definition camera. Nasal dosimetry was characterized in two transparent nasal cavity casts (normal and decongested) under two breathing conditions (breath-holding and constant inhalation). The nasal formulation was a 0.25% w/v methyl cellulose aqueous solution with a fluorescent dye. For each test case, the temporospatial spray translocation in the nasal cavity was recorded, and the final delivered doses were quantified in five nasal regions. The results indicate minor differences in droplet size distribution between the two devices. The nasal plume from the new device presents a narrower plume angle. The head orientation, the depth at which the nozzle is inserted into the nostril, and the administration angle play crucial roles in determining the initial deposition of nasal sprays as well as the subsequent translocation of the liquid film/droplets. Quantitative measurements of deposition distributions in the nasal models were augmented with visualization recordings to evaluate the delivery enhancements introduced by the new device. With an extension tube, the modified device produced a lower spray output and delivered lower doses in the front, middle, and back turbinate than the conventional nasal pump. However, sprays from the new device were observed to penetrate deeper into the nasal passages, predominantly through the middle-upper meatus. This resulted in consistently enhanced dosing in the middle-upper turbinate regions while at the cost of higher drug loss to the pharynx. Full article
(This article belongs to the Special Issue Challenges and Innovative Solutions in Nasal Drug Delivery: From Formulation Development to Mode of Administration, 2nd Edition)
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