Mesoporous Silica for Sustained Drug Release

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 1113

Special Issue Editors

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
Interests: mesoporous silica nanoparticles; nanocarrier design; intelligent drug delivery system
School of Pharmacy, China Medical University, Shenyang 110122, China
Interests: mesoporous silica nanoparticles; chiral mesoporous silica; oral adsorption; drug delivery systems

Special Issue Information

Dear Colleagues,

Mesoporous silica nanoparticles (MSNs), with diversification in shape, size and pore properties, have attracted an extensive attention in biomedical fields due to their distinct morphological features and unique physico-chemical properties. Compared to organic nanocarriers, inorganic rigid MSNs exhibit chemical/thermal stability, and can protect their cargo under broad ranges of temperatures and pHs. On the other hand, the well-developed and tunable pore networks of MSNs provide sufficient space for hosting various therapeutic agents, as well as controlling the drug loading and release kinetics. Furthermore, their internal/external surfaces show amenability of modification with a wide range of functional ligands or intelligent modes (stimuli-responsiveness, targeting, imaging, etc.), presenting a significant potential for drug delivery. In this Special Issue, we invite outstanding researchers around the world active in this field to contribute with research relating the design and synthesis of novel MSNs, sustained/controlled/stimuli-responsiveness/intelligent drug release systems based on MSNs and the drug delivery systems based on MSNs for the diagnosis and treatment of diseases, to provide readers the timely research progress from multiple perspectives.

Dr. Lu Xu
Dr. Heran Li
Guest Editors

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Keywords

  • mesoporous silica nanoparticles
  • drug delivery systems
  • sustained drug release
  • active targeting therapy
  • treatment of diseases

Published Papers (1 paper)

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Research

20 pages, 7546 KiB  
Article
Using Mesoporous Silica-Based Dual Biomimetic Nano-Erythrocytes for an Improved Antitumor Effect
by Ziyue Xi, Yingying Jiang, Zitong Ma, Qun Li, Xinran Xi, Chuanyong Fan, Shuang Zhu, Junjie Zhang and Lu Xu
Pharmaceutics 2023, 15(12), 2785; https://doi.org/10.3390/pharmaceutics15122785 - 15 Dec 2023
Viewed by 897
Abstract
The nano-delivery system with a dual biomimetic effect can penetrate deeper in tumor microenvironments (TMEs) and release sufficient antitumor drugs, which has attracted much attention. In this study, we synthesized erythrocyte-like mesoporous silica nanoparticles (EMSNs) as the core loaded with doxorubicin (DOX) and [...] Read more.
The nano-delivery system with a dual biomimetic effect can penetrate deeper in tumor microenvironments (TMEs) and release sufficient antitumor drugs, which has attracted much attention. In this study, we synthesized erythrocyte-like mesoporous silica nanoparticles (EMSNs) as the core loaded with doxorubicin (DOX) and coated them with calcium phosphate (CaP) and erythrocyte membrane (EM) to obtain DOX/EsPMs. The transmission electron microscopy (TEM), fluorescent co-localization and protein bands of SDS-PAGE were used to confirm the complete fabrication of EsPMs. The EsPMs with erythrocyte-like shape exhibited superior penetration ability in in vitro diffusion and tumor-sphere penetration experiments. Intracellular Ca2+ and ROS detection experiments showed that the CaP membranes of EsPMs with pH-sensitivity could provide Ca2+ continuously to induce reactive oxide species’ (ROS) generation in the TME. The EM as a perfect “camouflaged clothing” which could confuse macrophagocytes into prolonging blood circulation. Hemolysis and non-specific protein adsorption tests proved the desirable biocompatibility of EsPMs. An in vivo pharmacodynamics evaluation showed that the DOX/EsPMs group had a satisfactory tumor-inhibition effect. These advantages of the nano-erythrocytes suggest that by modifying the existing materials to construct a nano-delivery system, nanoparticles will achieve a biomimetic effect from both their structure and function with a facilitated and sufficient drug release profile, which is of great significance for antitumor therapy. Full article
(This article belongs to the Special Issue Mesoporous Silica for Sustained Drug Release)
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