Pharmaceutics

Journal Browser

► Journal Browser

Special Issue Editors

Prof. Dr. Aliaa N. ElMeshad

E-Mail Website
Guest Editor

1. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
2. Department of Pharmaceutics, Faculty of Pharmacy and Drug Technology, The Egyptian Chinese University, Cairo 11786, Egypt
Interests: nanotechnology as drug delivery systems to protein delivery; phytomedicine; tissue regeneration; application of photodynamic therapy

Dr. Dina Mahmoud

E-Mail Website
Guest Editor

Pharmaceutical Technology, Institute of Pharmacy, Faculty of Medicine, Leipzig University, 04317 Leipzig, Germany
Interests: drug delivery; 3D printing; hydrogels; microparticles; nanovesicles

Special Issue Information

Dear Colleagues,

In this Special Issue of Pharmaceutics: “Novel Biomaterials for Tissue Engineering and Regenerative Medicine”, an array of recent developments in fabrication methods of biomaterials and implants in tissue engineering, wound healing and bone regeneration are discussed. Novel biomaterials outperform conventional substrates in terms of tissue compatibility and safety. Novel biomaterials, spanning from nanofibrous scaffolds to metallic-based implants or a mixture of elements as nano-clays, have exhibited encouraging results in recent studies. The use of novel biomaterials in tissue regeneration is such a hot topic that led to the shift and attention of the research to this field. The ability to heal fast has always been a trait of Superheros, but the use of novel and safe biomaterials in tissue regeneration is making this dream a reality for normal people. In addition, the success of the earlier Pharmaceutics Special Issue: “Novel Nano-Engineered Biomaterials for Bone Tissue Engineering” led to the dedication of another Special Issue in this field on a broader tissue level. The application of novel biomaterials in tissue engineering and regenerative medicine with the associated fast technology transfer will be the focus of this Special Issue.

Prof. Dr. Aliaa N. ElMeshad
Dr. Dina B. Mahmoud
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

scaffold
nanofibers
hydrogels
implantable
in situ
nanoclay
biocompatibility
tissue engineering
wound healing
regenerative medicine

Published Papers (1 paper)

Research

31 pages, 4119 KiB

Open AccessArticle

Cross-Linked Alginate Dialdehyde/Chitosan Hydrogel Encompassing Curcumin-Loaded Bilosomes for Enhanced Wound Healing Activity

by Sarah A. Sideek, Hala B. El-Nassan, Ahmed R. Fares, Nermeen A. Elkasabgy and Aliaa N. ElMeshad

Pharmaceutics 2024, 16(1), 90; https://doi.org/10.3390/pharmaceutics16010090 - 9 Jan 2024

Cited by 1 | Viewed by 1135

Abstract

The current study aimed to fabricate curcumin-loaded bilosomal hydrogel for topical wound healing purposes, hence alleviating the poor aqueous solubility and low oral bioavailability of curcumin. Bilosomes were fabricated via the thin film hydration technique using cholesterol, Span^® 60, and two different types of bile salts (sodium deoxycholate or sodium cholate). Bilosomes were verified for their particle size (PS), polydispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE%), and in vitro drug release besides their morphological features. The optimum formulation was composed of cholesterol/Span^® 60 (molar ratio 1:10 w/w) and 5 mg of sodium deoxycholate. This optimum formulation was composed of a PS of 246.25 ± 11.85 nm, PDI of 0.339 ± 0.030, ZP of −36.75 ± 0.14 mv, EE% of 93.32% ± 0.40, and the highest percent of drug released over three days (96.23% ± 0.02). The optimum bilosomal formulation was loaded into alginate dialdehyde/chitosan hydrogel cross-linked with calcium chloride. The loaded hydrogel was tested for its water uptake capacity, in vitro drug release, and in vivo studies on male Albino rats. The results showed that the loaded hydrogel possessed a high-water uptake percent at the four-week time point (729.50% ± 43.13) before it started to disintegrate gradually; in addition, it showed sustained drug release for five days (≈100%). In vivo animal testing and histopathological studies supported the superiority of the curcumin-loaded bilosomal hydrogel in wound healing compared to the curcumin dispersion and plain hydrogel, where there was a complete wound closure attained after the three-week period with a proper healing mechanism. Finally, it was concluded that curcumin-loaded bilosomal hydrogel offered a robust, efficient, and user-friendly dosage form for wound healing. Full article

(This article belongs to the Special Issue Novel Biomaterials for Tissue Engineering and Regenerative Medicine)

► Show Figures