Nanoparticle-Mediated Diagnostics and Drug Delivery Therapy

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 24 August 2024 | Viewed by 1968

Special Issue Editors


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Guest Editor
Laboratory of Surface Phenomena in Polymer Systems, Frumkin Institute of Physical Chemistry and Electrochemistry of Russian Academy of Sciences, Leninskiy Prosp. 31, Building 4, 119071 Moscow, Russia
Interests: nanoparticles synthesis; drug delivery; tumor theranostics; nanoparticles assembly; nanocomposites

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Guest Editor
Laboratory of Physical Chemistry of Colloidal Systems, Frumkin Institute of Physical Chemistry and Electrochemistry of Russian Academy of Sciences, Leninskiy Prosp. 31, Building 4, 119071 Moscow, Russia
Interests: nanoparticles synthesis; polymers; nanomaterials; composites; antibacterial activity

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Guest Editor
Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, Russia
Interests: polyelectrolytes; liposomes; interfacial complexes; drug delivery; nanocontainers; micelles; biocides
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Special Issue Information

Dear Colleagues,

Increasing the treatment efficiency of various dangerous diseases is among the most urgent tasks of modern medicine. The primary ways to solve the issue are to develop methods for the early diagnosis of diseases and to the performance of minimally invasive therapy (including by means of targeted delivery and controlled release of drugs). Such delivery can significantly reduce the risk of side effects and, as a result, increase the patient's quality of life.

The use of different nanoparticles as diagnostic tools or drug carriers is of significant interest from both scientific and practical points of view, as the distribution of such nanocarriers in the body can be controlled by varying their size and/or surface chemistry. In addition, they can serve not only in diagnosis or transport, but also as therapeutic agents, acting as sensitizers of one or another external influence (radiation, laser, ultrasonic, etc.). As a result, it becomes possible to combine different types of therapy.

This Special Issue aims to bring together reviews and experimental works reflecting the main trends, challenges and latest advances in the creation and practical usage of nanoparticles that are capable of serving as diagnostic and drug delivery tools.

Dr. Olga V. Dement'eva
Dr. Ivan N. Senchikhin
Dr. Andrey V. Sybachin
Guest Editors

Manuscript Submission Information

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Keywords

  • nanomaterials for diseases theranostics
  • nanomaterials for multimodal therapy
  • nanomaterials for diagnostics
  • stimuli responsive nanocarriers
  • biodegradable nanocarriers
  • the routes of drug nanocarriers’ administration
  • active and passive targeting of nanocarriers
  • nanocarriers biodistribution
  • toxicity of nanocarriers
  • delivery of hydrophobic drugs
  • microemulsions as drug delivery systems
  • drug encapsulation methods
  • drug release models

Published Papers (1 paper)

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Research

18 pages, 5683 KiB  
Article
Formation Kinetics and Antimicrobial Activity of Silver Nanoparticle Dispersions Based on N-Reacetylated Oligochitosan Solutions for Biomedical Applications
by Ekaterina K. Urodkova, Ol’ga Ya. Uryupina, Vladimir E. Tikhonov, Natalia E. Grammatikova, Anastasia V. Bol’shakova, Anna A. Sinelshchikova, Alexandra I. Zvyagina, Dmitry N. Khmelenin, Elena S. Zhavoronok and Ivan N. Senchikhin
Pharmaceutics 2023, 15(12), 2690; https://doi.org/10.3390/pharmaceutics15122690 - 28 Nov 2023
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Abstract
The paper presents the results of the synthesis, a detailed kinetics study, and an investigation of the biological activity of silver nanoparticles (AgNPs) in aqueous solutions of N-reacetylated oligochitosan hydrochloride. UV–visible spectrophotometry and dynamic light scattering were employed to control silver ion reduction. [...] Read more.
The paper presents the results of the synthesis, a detailed kinetics study, and an investigation of the biological activity of silver nanoparticles (AgNPs) in aqueous solutions of N-reacetylated oligochitosan hydrochloride. UV–visible spectrophotometry and dynamic light scattering were employed to control silver ion reduction. The process was observed to follow a pseudo-first-order law. Transmission and scanning electron microscopy demonstrated that AgNPs ranging in size from 10 to 25 nm formed aggregates measuring 60 to 90 nm, with the aggregate surface coated by a 2–4 nm chitosan shell. X-ray microanalysis and powder X-ray diffractometry were used to study the phase composition, identifying two crystalline phases, nanocrystalline silver and AgCl, present in the dispersions. The antibacterial effect was assessed using the serial dilution method for dispersions with varying degrees of Ag+ conversion. Nanodispersions exhibited significant activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, and Staphylococcus aureus. Interestingly, the activity did not appear to be heavily influenced by the presence of the AgCl phase or the concentration of Ag+ ions. These synthesized dispersions hold promise for the development of materials tailored for biomedical applications. Full article
(This article belongs to the Special Issue Nanoparticle-Mediated Diagnostics and Drug Delivery Therapy)
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