Special Issue "Mitochondrial Target-Based Drug Discovery"


A special issue of Pharmaceuticals (ISSN 1424-8247).

Deadline for manuscript submissions: closed (31 March 2014)

Special Issue Editors

Guest Editor
Prof. Dr. Philip Hogg
Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
Website: http://powcs.med.unsw.edu.au/people/professor-philip-hogg
E-Mail: p.hogg@unsw.edu.au
Phone: +61 2 9385 1004
Fax: +61 2 9385 1510
Interests: allosteric disulfide bonds; small molecule mitochondrial pharmaceuticals; cancer

Guest Editor
Dr. Pierre Dilda
Prince of Wales Clinical School, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia
Website: http://powcs.med.unsw.edu.au/people/dr-pierre-dilda
E-Mail: p.dilda@unsw.edu.au
Interests: drug discovery; cancer drug development and pharmacology; drug resistance; medicinal chemistry; arsenical-based drugs

Special Issue Information

Dear Colleagues,

Compared to healthy cells, cancerous ones catabolize nutrients differently. Mitochondria play a central role in this altered metabolism. Mitochondria coordinate the catabolism of glucose and glutamine across the cancer cell. Disrupting this metabolism may potentially treat the disease. This special issue focuses on small molecules that inhibit the cancer cell mitochondrial metabolism, which are in pre-clinical or clinical development.

Prof. Dr. Philip Hogg
Dr. Pierre Dilda
Guest Editors


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 800 CHF (Swiss Francs).


  • cancer
  • mitochondria
  • metabolism
  • outer-mitochondrial membrane
  • inner-mitochondrial membrane
  • mitochondrial matrix

Published Papers (3 papers)

by , , , , , ,  and
Pharmaceuticals 2014, 7(8), 894-912; doi:10.3390/ph7080894
Received: 28 April 2014; in revised form: 22 July 2014 / Accepted: 13 August 2014 / Published: 22 August 2014
Show/Hide Abstract | PDF Full-text (2285 KB) | HTML Full-text | XML Full-text

by , ,  and
Pharmaceuticals 2014, 7(8), 881-893; doi:10.3390/ph7080881
Received: 15 April 2014; in revised form: 15 July 2014 / Accepted: 15 August 2014 / Published: 21 August 2014
Show/Hide Abstract | PDF Full-text (1897 KB) | Supplementary Files
abstract graphic

Pharmaceuticals 2014, 7(2), 192-206; doi:10.3390/ph7020192
Received: 10 January 2014; in revised form: 29 January 2014 / Accepted: 6 February 2014 / Published: 11 February 2014
Show/Hide Abstract | PDF Full-text (421 KB) | HTML Full-text | XML Full-text

Last update: 3 February 2014

Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert