Special Issue "Ion Channels as Therapeutic Targets for Pain"

Quicklinks

A special issue of Pharmaceuticals (ISSN 1424-8247).

Deadline for manuscript submissions: closed (30 April 2010)

Special Issue Editor

Guest Editor
Prof. Dr. Mark A. Schumacher
Department of Anesthesia and Perioperative Care, School of Medicine, University of California, San Francisco, 521 Parnassus Avenue, (0648), San Francisco, CA 94143-0648, USA
E-Mail: schumacm@anesthesia.ucsf.edu
Interests: capsaicin receptor; gene; genomics; Nerve Growth Factor (NGF); nociceptor; pain; promoter; splice variant; transcription factor-Sp1; TRPV1; VR1

Special Issue Information

Dear Colleagues,

Pain still remains an immense clinical challenge. Our ability to effectively treat acute and especially chronic painful conditions often causes unwanted side-effects that degrade the quality of life. The last decade has seen an explosive growth in our understanding of how the sensation of pain is initiated at the peripheral terminals of primary afferent neurons – nociceptors. These specialized nerve terminals express a diverse array of ion channel - receptors that transduce noxious chemical, thermal and mechanical stimuli. Together, these ion channels serve to detect impending and ongoing tissue damage arising from pathophysiologic states such as inflammation and nerve injury. This section will focus on the therapeutic potential of targeting specific ion channels expressed in nociceptors to more effectively treat painful conditions.

Prof. Dr. Mark A. Schumacher
Guest Editor

Keywords

  • TRP channels
  • capsaicin receptor
  • TRPV1
  • TRPA1
  • TRPV4
  • P2X
  • purinergic receptor
  • calcium channel
  • ASIC
  • acid sensing channel
  • sodium channel
  • NaV 1.8
  • NaV 1.9
  • TTX-R sodium channel
  • potassium channel – two pore
  • pain
  • primary afferent nociceptor
  • analgesia
  • nociception

Published Papers (4 papers)

Download All Papers
Sort by:
Display options:
Select articles Export citation of selected articles as:
Select/unselect all
Displaying article 1-4
p. 2768-2798
by , , ,  and
Pharmaceuticals 2010, 3(9), 2768-2798; doi:10.3390/ph3092768
Received: 13 July 2010; in revised form: 5 August 2010 / Accepted: 20 August 2010 / Published: 26 August 2010
Show/Hide Abstract | Cited by 3 | PDF Full-text (563 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Ion Channels as Therapeutic Targets for Pain)
p. 2248-2267
by , , , , ,  and
Pharmaceuticals 2010, 3(7), 2248-2267; doi:10.3390/ph3072248
Received: 17 May 2010; in revised form: 28 June 2010 / Accepted: 15 July 2010 / Published: 19 July 2010
Show/Hide Abstract | Cited by 2 | PDF Full-text (203 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Ion Channels as Therapeutic Targets for Pain)
abstract graphic
p. 2178-2196
by
Pharmaceuticals 2010, 3(7), 2178-2196; doi:10.3390/ph3072178
Received: 27 May 2010; in revised form: 10 June 2010 / Accepted: 6 July 2010 / Published: 8 July 2010
Show/Hide Abstract | Cited by 1 | PDF Full-text (516 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Ion Channels as Therapeutic Targets for Pain)
p. 1411-1425
by  and
Pharmaceuticals 2010, 3(5), 1411-1425; doi:10.3390/ph3051411
Received: 2 April 2010; in revised form: 14 April 2010 / Accepted: 7 May 2010 / Published: 11 May 2010
Show/Hide Abstract | Cited by 1 | PDF Full-text (164 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Ion Channels as Therapeutic Targets for Pain)
Select/unselect all
Displaying article 1-4
Select articles Export citation of selected articles as:

Last update: 4 March 2014

Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert