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Pharmaceuticals 2010, 3(7), 2248-2267; doi:10.3390/ph3072248
Review

Emerging Families of Ion Channels Involved in Urinary Bladder Nociception

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Received: 17 May 2010 / Revised: 28 June 2010 / Accepted: 15 July 2010 / Published: 19 July 2010
(This article belongs to the Special Issue Ion Channels as Therapeutic Targets for Pain)
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Abstract

The expression of multiple ion channels and receptors is essential for nociceptors to detect noxious stimuli of a thermal, mechanical or chemical nature. The peripheral sensory transduction systems of the urinary bladder include sensory nerve endings, urothelial cells and others whose location is suitable for transducing mechanical and chemical stimuli. There is an increasing body of evidence implicating the Deg/ENaC and TRP channel families in the control of bladder afferent excitability under physiological and pathological conditions. Pharmacological interventions targeting these ion channels may provide a new strategy for the treatment of pathological bladder sensation and pain.
Keywords: ion channel; urinary bladder; sensation; nociception; transient receptor potential ion channel; urinary bladder; sensation; nociception; transient receptor potential
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Araki, I.; Yoshiyama, M.; Kobayashi, H.; Mochizuki, T.; Du, S.; Okada, Y.; Takeda, M. Emerging Families of Ion Channels Involved in Urinary Bladder Nociception. Pharmaceuticals 2010, 3, 2248-2267.

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