Pharmaceuticals 2010, 3(9), 2768-2798; doi:10.3390/ph3092768
Review

Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain

Stuart M. Brierley 1,2,3,* email, Patrick A. Hughes 1,2 email, Andrea M. Harrington 1,2 email, Grigori Y. Rychkov 3 email and L. Ashley Blackshaw 1,2,3 email
1 Nerve-Gut Research Laboratory, Department of Gastroenterology & Hepatology, Hanson Institute, Royal Adelaide Hospital, Adelaide, South Australia, 5000, Australia 2 Disciplines of Medicine, The University of Adelaide, Adelaide, South Australia, 5000, Australia 3 Disciplines of Physiology, The University of Adelaide, Adelaide, South Australia, 5000, Australia
* Author to whom correspondence should be addressed.
Received: 13 July 2010; in revised form: 5 August 2010 / Accepted: 20 August 2010 / Published: 26 August 2010
(This article belongs to the Special Issue Ion Channels as Therapeutic Targets for Pain)
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Abstract: We are normally unaware of the complex signalling events which continuously occur within our internal organs. Most of us only become cognisant when sensations of hunger, fullness, urgency or gas arise. However, for patients with organic and functional bowel disorders pain is an unpleasant and often debilitating reminder. Furthermore, chronic pain still represents a large unmet need for clinical treatment. Consequently, chronic pain has a considerable economic impact on health care systems and the afflicted individuals. In order to address this need we must understand how symptoms are generated within the gut, the molecular pathways responsible for generating these signals and how this process changes in disease states.
Keywords: TRPA1; TRPV4; TRPV1; ASICs; NaV and KV channels; visceral pain

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Cite This Article

MDPI and ACS Style

Brierley, S.M.; Hughes, P.A.; Harrington, A.M.; Rychkov, G.Y.; Blackshaw, L.A. Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain. Pharmaceuticals 2010, 3, 2768-2798.

AMA Style

Brierley SM, Hughes PA, Harrington AM, Rychkov GY, Blackshaw LA. Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain. Pharmaceuticals. 2010; 3(9):2768-2798.

Chicago/Turabian Style

Brierley, Stuart M.; Hughes, Patrick A.; Harrington, Andrea M.; Rychkov, Grigori Y.; Blackshaw, L. Ashley. 2010. "Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain." Pharmaceuticals 3, no. 9: 2768-2798.

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