Abstract: We are normally unaware of the complex signalling events which continuously occur within our internal organs. Most of us only become cognisant when sensations of hunger, fullness, urgency or gas arise. However, for patients with organic and functional bowel disorders pain is an unpleasant and often debilitating reminder. Furthermore, chronic pain still represents a large unmet need for clinical treatment. Consequently, chronic pain has a considerable economic impact on health care systems and the afflicted individuals. In order to address this need we must understand how symptoms are generated within the gut, the molecular pathways responsible for generating these signals and how this process changes in disease states.
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Brierley, S.M.; Hughes, P.A.; Harrington, A.M.; Rychkov, G.Y.; Blackshaw, L.A. Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain. Pharmaceuticals 2010, 3, 2768-2798.
Brierley SM, Hughes PA, Harrington AM, Rychkov GY, Blackshaw LA. Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain. Pharmaceuticals. 2010; 3(9):2768-2798.
Brierley, Stuart M.; Hughes, Patrick A.; Harrington, Andrea M.; Rychkov, Grigori Y.; Blackshaw, L. Ashley. 2010. "Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain." Pharmaceuticals 3, no. 9: 2768-2798.