Next Article in Journal
Vulnerability Factors for the Psychiatric and Behavioral Effects of Cannabis
Previous Article in Journal
Clinical Toxicities of Histone Deacetylase Inhibitors
Previous Article in Special Issue
Emerging Families of Ion Channels Involved in Urinary Bladder Nociception
Pharmaceuticals 2010, 3(9), 2768-2798; doi:10.3390/ph3092768
Review

Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain

1,2,3,* , 1,2
, 1,2
, 3
 and 1,2,3
Received: 13 July 2010; in revised form: 5 August 2010 / Accepted: 20 August 2010 / Published: 26 August 2010
(This article belongs to the Special Issue Ion Channels as Therapeutic Targets for Pain)
View Full-Text   |   Download PDF [563 KB, uploaded 26 August 2010]   |   Browse Figures
Abstract: We are normally unaware of the complex signalling events which continuously occur within our internal organs. Most of us only become cognisant when sensations of hunger, fullness, urgency or gas arise. However, for patients with organic and functional bowel disorders pain is an unpleasant and often debilitating reminder. Furthermore, chronic pain still represents a large unmet need for clinical treatment. Consequently, chronic pain has a considerable economic impact on health care systems and the afflicted individuals. In order to address this need we must understand how symptoms are generated within the gut, the molecular pathways responsible for generating these signals and how this process changes in disease states.
Keywords: TRPA1; TRPV4; TRPV1; ASICs; NaV and KV channels; visceral pain TRPA1; TRPV4; TRPV1; ASICs; NaV and KV channels; visceral pain
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Brierley, S.M.; Hughes, P.A.; Harrington, A.M.; Rychkov, G.Y.; Blackshaw, L.A. Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain. Pharmaceuticals 2010, 3, 2768-2798.

AMA Style

Brierley SM, Hughes PA, Harrington AM, Rychkov GY, Blackshaw LA. Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain. Pharmaceuticals. 2010; 3(9):2768-2798.

Chicago/Turabian Style

Brierley, Stuart M.; Hughes, Patrick A.; Harrington, Andrea M.; Rychkov, Grigori Y.; Blackshaw, L. Ashley. 2010. "Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain." Pharmaceuticals 3, no. 9: 2768-2798.


Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert