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Pharmaceuticals 2010, 3(5), 1411-1425; doi:10.3390/ph3051411
Review

Acid-Sensing Ion Channels and Pain

*  and
Department of Physiology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536-0298, USA
* Author to whom correspondence should be addressed.
Received: 2 April 2010 / Revised: 14 April 2010 / Accepted: 7 May 2010 / Published: 11 May 2010
(This article belongs to the Special Issue Ion Channels as Therapeutic Targets for Pain)
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Abstract

Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management.
Keywords: acid sensing ion channel; acidosis; inflammation; nociceptor; pain acid sensing ion channel; acidosis; inflammation; nociceptor; pain
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Gu, Q.; Lee, L.-Y. Acid-Sensing Ion Channels and Pain. Pharmaceuticals 2010, 3, 1411-1425.

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