Pharmaceuticals 2010, 3(5), 1411-1425; doi:10.3390/ph3051411

Acid-Sensing Ion Channels and Pain

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Received: 2 April 2010; in revised form: 14 April 2010 / Accepted: 7 May 2010 / Published: 11 May 2010
(This article belongs to the Special Issue Ion Channels as Therapeutic Targets for Pain)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management.
Keywords: acid sensing ion channel; acidosis; inflammation; nociceptor; pain
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MDPI and ACS Style

Gu, Q.; Lee, L.-Y. Acid-Sensing Ion Channels and Pain. Pharmaceuticals 2010, 3, 1411-1425.

AMA Style

Gu Q, Lee L-Y. Acid-Sensing Ion Channels and Pain. Pharmaceuticals. 2010; 3(5):1411-1425.

Chicago/Turabian Style

Gu, Qihai; Lee, Lu-Yuan. 2010. "Acid-Sensing Ion Channels and Pain." Pharmaceuticals 3, no. 5: 1411-1425.

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