Special Issue "Anti-Infective Agents"
A special issue of Pharmaceuticals (ISSN 1424-8247).
Deadline for manuscript submissions: closed (31 March 2010)
Prof. Dr. Mark Hamann (Website)
Department of Pharmacognosy and The National Center for the Development of Natural Products, University of Mississippi, USA
Interests: natural products; antiinfectives; anticancer agents; NMR spectroscopy; marine ecology; synthesis of natural products; biosynthesis
Prof. Dr. Paul Cos (Website)
Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences Antwerp University, campus drie eiken, building S, office 7.26 Universiteitsplein 1, B-2610 Antwerp, Belgium
Interests: anti-infective agents; biofilm; bacterial virulence; oxidative stress; antibacterial; antifungal; antiparasitic and antiviral
Despite the tremendous progress in human medicine, infectious diseases represent one of the greatest challenges to mankind in the 21st century. According to WHO, infectious diseases account for nearly a third of global deaths. AIDS, malaria, tuberculosis and respiratory infections were among the top eight leading causes of death in 2004. The burden of infectious diseases falls particularly on the less developed countries due to the relative unavailability of medicines and the emergence of widespread drug resistance. In developing countries, a high infectious disease burden commonly co-exists with rapid emergence and spread of microbial resistance. The growing threat of emerging diseases such as SARS and influenza A (H1N1) has served as a wake-up call to public health services, pharmaceutical industry and academia.
Because the evolution of drug resistance is likely to compromise every drug in time, research on new anti-infective agents must be continued and all possible strategies should be explored. Besides small molecules from medicinal chemistry, natural products are still major sources of innovative therapeutic agents for various conditions, including infectious diseases.
This special issue welcomes research articles and comprehensive reviews addressing the discovery and/or development of anti-infective agents.
Prof. Dr. Paul Cos
Prof. Dr. Mark Hamann
- bacterial virulence
- oxidative stress
- small molecules
- natural products