Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Pharmaceuticals 2010, 3(9), 2900-2909; doi:10.3390/ph3092900
Article

Antifungal Properties of Chenopodium ambrosioides Essential Oil Against Candida Species

1, 1, 1, 1,* , 3, 2 and 2
Received: 15 May 2010; in revised form: 6 July 2010 / Accepted: 14 July 2010 / Published: 1 September 2010
(This article belongs to the Special Issue Anti-Infective Agents)
View Full-Text   |   Download PDF [385 KB, uploaded 1 September 2010]
Abstract: The essential oil of the aerial part (leaves, flowers and stem) of Chenopodium ambrosioides was obtained by hydrodistillation and its chemical composition analyzed by GC and GC/MS, which permitted the identification of 14 components, representing 98.8% of the total oil. Major components were α-terpinene (51.3%), p-cymene (23.4%) and p-mentha-1,8-diène (15.3%). The antifungal properties of this essential oil were investigated in vitro by the well diffusion and broth microdilution methods. The in vitro antifungal activity was concentration dependent and minimum inhibitory concentration values varied from 0.25 to 2 mg/mL. The in vivo antifungal activity was evaluated on an induced vaginal candidiasis rat model. The in vivo activity of the oil on mice vaginal candidiasis was not dose-dependent. Indeed, all the three tested doses; 0.1%, 1% and 10% led to the recovery of mice from the induced infection after 12 days of treatment. The effect of the essential oil on C. albicans ATCC 1663 fatty acid profile was studied. This oil has a relatively important dose-dependent effect on the fatty acids profile.
Keywords: Chenopodium ambrosioides; essential oil; antifungal; yeasts; fatty acids profile Chenopodium ambrosioides; essential oil; antifungal; yeasts; fatty acids profile
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Chekem, M.S.G.; Lunga, P.K.; Tamokou, J.D.D.; Kuiate, J.R.; Tane, P.; Vilarem, G.; Cerny, M. Antifungal Properties of Chenopodium ambrosioides Essential Oil Against Candida Species. Pharmaceuticals 2010, 3, 2900-2909.

AMA Style

Chekem MSG, Lunga PK, Tamokou JDD, Kuiate JR, Tane P, Vilarem G, Cerny M. Antifungal Properties of Chenopodium ambrosioides Essential Oil Against Candida Species. Pharmaceuticals. 2010; 3(9):2900-2909.

Chicago/Turabian Style

Chekem, Marie Stéphanie Goka; Lunga, Paul Keilah; Tamokou, Jean De Dieu; Kuiate, Jules Roger; Tane, Pierre; Vilarem, Gerard; Cerny, Muriel. 2010. "Antifungal Properties of Chenopodium ambrosioides Essential Oil Against Candida Species." Pharmaceuticals 3, no. 9: 2900-2909.



Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert