Special Issue "Applications of Microemulsions in Biomedical Research"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 31 August 2018

Special Issue Editor

Guest Editor
Prof. Dr. Amnon Sintov

Ben-Gurion University of the Negev, Department of Biomedical Engineering, Be’er Sheva 84105, Israel
Website | E-Mail
Interests: transdermal and topical drug delivery; intranasal administration of nano-metric systems; microemulsions; nanoparticles; biopharmaceutics

Special Issue Information

Dear Colleagues,

Since the discovery of microemulsions (MEs or mEs) by Hoar and Schulman (Nature, 152:102, 1943), there has been a huge interest in these systems, as evidenced by their extensive worldwide use in diverse research areas, in many products, and in various industrial processes. Due to their unique properties as potential nanocarriers, the application of MEs in drug therapeutics is an important issue that should be specifically addressed. Thus, in an attempt to highlight the medical uses and applications related to MEs, Nanomaterials has decided to publish a Special Issue “Applications of Microemulsions in Biomedical Research” that will focus on recent studies and development of MEs as delivery systems for drugs and therapeutic agents.

The Special Issue of Nanomaterials will include:

·         Recent advances in theoretical modeling of drug solubilization and release from microemulsions.
·         Oral delivery and intestinal absorption of drug-loaded microemulsions.
·         Delivery of protein and peptide drugs via microemulsions.
·         Parenteral delivery and tumor targeting.
·         Topical and dermatological use.
·         Intranasal and brain targeting.
·         Other applications (e.g., ophthalmic, periodontal).
·         Use of microemulsions as a template to manufacture other drug nanocarriers

Prof. Dr. Amnon Sintov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Microemulsion
  • Self-assembling nanostructures
  • Enhanced drug delivery
  • Increased drug bioavailability
  • Protein and peptide drug delivery
  • Sustained and targeted drug delivery

Published Papers (1 paper)

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Open AccessArticle Fatty Acid Based Microemulsions to Combat Ophthalmia Neonatorum Caused by Neisseria gonorrhoeae and Staphylococcus aureus
Nanomaterials 2018, 8(1), 51; doi:10.3390/nano8010051
Received: 29 November 2017 / Revised: 5 January 2018 / Accepted: 8 January 2018 / Published: 19 January 2018
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The bacterial species Neisseria gonorrhoeae (N. gonorrhoeae) and Staphylococcus aureus (S. aureus) are amongst the main microorganisms that cause ophthalmia neonatorum. The current treatment involves the use of various antibiotics such as ciprofloxacin, cephalosporin, ceftriaxone and cefotaxime. However, this
[...] Read more.
The bacterial species Neisseria gonorrhoeae (N. gonorrhoeae) and Staphylococcus aureus (S. aureus) are amongst the main microorganisms that cause ophthalmia neonatorum. The current treatment involves the use of various antibiotics such as ciprofloxacin, cephalosporin, ceftriaxone and cefotaxime. However, this treatment strategy is becoming more ineffective due to the antibiotic resistance in N. gonorrhoeae. The current study explores the potential use of fatty acid based microemulsions (ME) to prevent N. gonorrhoeae and S. aureus infections in new-borns’ eyes without harmful side effects such as corneal or conjunctiva irritation. Pseudo-ternary phase diagrams were constructed to evaluate microemulsion regions and six different α-linolenic acid based microemulsions were prepared. The prepared formulations were characterized for α-linolenic acid content, size, transparency, zeta potential, Polarized light Microscopy, antimicrobial activity and ex vivo ocular toxicity. The mean droplet size of the ME formulations was in the range of 190.4 to 350.5 nm and polydispersity index (PDI) values were in the range of 0.102 to 0.561. All formulations were found stable upon storage for at least 8 weeks. In addition, self-diffusion coefficients determined by nuclear magnetic resonance (NMR) reflected that the diffusability of water increased at higher than 30% w/w water, while that of fatty acids and surfactants was in reverse. The antimicrobial efficacy of microemulsions was determined against N. gonorrhoeae and S. aureus. It was concluded that all microemulsions have strong antimicrobial effects against N. gonorrhoeae and S. aureus. Finally, bovine corneal opacity permeability (BCOP) and hen’s egg chorioallantoic (HET-CAM) tests results showed that all microemulsion formulations were not strong ocular irritants. Full article
(This article belongs to the Special Issue Applications of Microemulsions in Biomedical Research)

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Studies on quercetin interactions with surfactant/solvent systems
Author: Alişan Güzeloğlu, Hanna Wilczura-Wachnik
Affiliation: Faculty of Chemistry, University of Warsaw
Abstract: Interactions of antioxidants with the biological membrane still are in the center of attention of scientists. Simple model systems as for example micelles due to their specific physico-chemical properties, and structural similarity to domains present in the cell membranes are used in these studies. In this work are presented a study on quercetin interactions with different types of micelles. Objects of our research were quercetin/solvent/surfactant/water systems. The UV-vis method and dynamic light scattering (DLS) technique were applied. The obtained results allowed the identification of preferred location places in the structure of micellar systems. Moreover the effect of surfactants concentrations and the presence of water on the value of distribution constant, and the binding constant in examined systems were discussed. In addition, there were discussed the quantitative data regarding the effects of quercetin and water presence on the micelles size and diffusion effects in studied systems.

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