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Special Issue "Suzuki Reaction"

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A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (30 November 2012)

Special Issue Editor

Guest Editor
Prof. Dr. Anna Trzeciak

Faculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie Str., 50-383 Wrocław, Poland
E-Mail
Phone: +48 71 3757253
Interests: coordination and organometallic chemistry; homogeneous and heterogenized metal complex catalysis; nanocatalysis; mechanistic studies of hydroformylation; palladium catalyzed C-C cross-coupling and carbonylation reactions; polymerization of phenylacetylene

Special Issue Information

Dear Colleagues,

Suzuki reaction presents one of the most useful methodologies applied for the synthesis of unsymmetrical biaryls, which are important components for pharmaceutical agents, organic materials and natural products.  Palladium compounds and palladium nanoparticles are today considered as the most active catalysts of Suzuki reaction, however there are also reports indicating on the possibility of successful application of other metals in this process. Moreover, improvement of reaction conditions to more environmentally friendly has been a highly topical field of study.
The aim of this special issue is to present the most actual trends in the area of Suzuki reaction.
Contributions for this issue, both in form of original research and review articles, may cover all aspects of Suzuki reaction e.g. application of Suzuki methodology for the synthesis of functionalized organic molecules and compounds of potential biological activity, new catalysts presenting high activity and selectivity, homogeneous, immobilized and heterogeneous catalysts for the Suzuki reaction, improvement of Suzuki reaction conditions by application of alternative energy sources and green solvents, mechanistic studies and identification of catalytically active species, asymmetric Suzuki reaction, Suzuki reaction as a part of tandem processes.

Prof. Dr. Anna Trzeciak
Guest Editor

Keywords

  • cross-coupling reactions
  • boronic acids
  • selectivity
  • functionalized biphenyls
  • homogeneous catalysts
  • heterogeneous catalysts
  • palladium
  • palladium nanoparticles
  • reaction mechanism
  • reaction media
  • asymmetric Suzuki reaction

Published Papers (3 papers)

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Research

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Open AccessArticle Cross-Coupling Reaction with Lithium Methyltriolborate
Molecules 2013, 18(1), 430-439; doi:10.3390/molecules18010430
Received: 4 December 2012 / Revised: 21 December 2012 / Accepted: 27 December 2012 / Published: 28 December 2012
Cited by 3 | PDF Full-text (215 KB)
Abstract
We newly developed lithium methyltriolborate as an air-stable white solid that is convenient to handle. The good performance of this triolborate for metal-catalyzed bond-forming reactions was demonstrated in palladium-catalyzed cross-coupling reactions with haloarenes. Cross-coupling reaction of [MeB(OCH2)3CCH3]Li
[...] Read more.
We newly developed lithium methyltriolborate as an air-stable white solid that is convenient to handle. The good performance of this triolborate for metal-catalyzed bond-forming reactions was demonstrated in palladium-catalyzed cross-coupling reactions with haloarenes. Cross-coupling reaction of [MeB(OCH2)3CCH3]Li with aryl halides occurred in the presence of Pd(OAc)2/RuPhos complex in refluxing MeOH/H2O and the absence of bases. Full article
(This article belongs to the Special Issue Suzuki Reaction)

Review

Jump to: Research

Open AccessReview Application of the Suzuki-Miyaura Reaction in the Synthesis of Flavonoids
Molecules 2013, 18(4), 4739-4765; doi:10.3390/molecules18044739
Received: 19 March 2013 / Revised: 10 April 2013 / Accepted: 19 April 2013 / Published: 22 April 2013
Cited by 18 | PDF Full-text (350 KB) | HTML Full-text | XML Full-text
Abstract
The application of the Suzuki-Miyaura reaction in the synthesis of flavonoids, an important class of natural products, is reviewed. This reaction has not only been employed to provide access to flavonoid nuclei, but has also been applied to the synthesis of dimeric flavonoids
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The application of the Suzuki-Miyaura reaction in the synthesis of flavonoids, an important class of natural products, is reviewed. This reaction has not only been employed to provide access to flavonoid nuclei, but has also been applied to the synthesis of dimeric flavonoids and in the synthesis of libraries of flavonoid derivatives for biological activity studies. The classes of flavonoids that are discussed are the chalcones, flavones, isoflavones, neoflavones, biflavones and derivatives of flavonoids obtained by C-C bond formation via the Suzuki-Miyaura reaction. Full article
(This article belongs to the Special Issue Suzuki Reaction)
Open AccessReview Suzuki-Miyaura Cross-Coupling in Acylation Reactions, Scope and Recent Developments
Molecules 2013, 18(1), 1188-1213; doi:10.3390/molecules18011188
Received: 19 December 2012 / Revised: 8 January 2013 / Accepted: 9 January 2013 / Published: 17 January 2013
Cited by 40 | PDF Full-text (472 KB)
Abstract
Since the first report and due to its handiness and wide scope, the Suzuki-Miyaura (SM) cross coupling reaction has become a routine methodology in many laboratories worldwide. With respect to other common transition metal catalyzed cross couplings, the SM reaction has been so
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Since the first report and due to its handiness and wide scope, the Suzuki-Miyaura (SM) cross coupling reaction has become a routine methodology in many laboratories worldwide. With respect to other common transition metal catalyzed cross couplings, the SM reaction has been so far less exploited as a tool to introduce an acyl function into a specific substrate. In this review, the various approaches found in the literature will be considered, starting from the direct SM acylative coupling to the recent developments of cross coupling between boronates and acyl chlorides or anhydrides. Special attention will be dedicated to the use of masked acyl boronates, alkoxy styryl and alkoxy dienyl boronates as coupling partners. A final section will be then focused on the acyl SM reaction as key synthetic step in the framework of natural products synthesis. Full article
(This article belongs to the Special Issue Suzuki Reaction)

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