Molecules 2013, 18(4), 4739-4765; doi:10.3390/molecules18044739
Review

Application of the Suzuki-Miyaura Reaction in the Synthesis of Flavonoids

School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Scottsville 3209, South Africa
* Author to whom correspondence should be addressed.
Received: 19 March 2013; in revised form: 10 April 2013 / Accepted: 19 April 2013 / Published: 22 April 2013
(This article belongs to the Special Issue Suzuki Reaction)
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Abstract: The application of the Suzuki-Miyaura reaction in the synthesis of flavonoids, an important class of natural products, is reviewed. This reaction has not only been employed to provide access to flavonoid nuclei, but has also been applied to the synthesis of dimeric flavonoids and in the synthesis of libraries of flavonoid derivatives for biological activity studies. The classes of flavonoids that are discussed are the chalcones, flavones, isoflavones, neoflavones, biflavones and derivatives of flavonoids obtained by C-C bond formation via the Suzuki-Miyaura reaction.
Keywords: Suzuki-Miyaura reaction; flavonoid; chalcone; flavone; isoflavone; neoflavone; 4-arylcoumarin; biflavone

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MDPI and ACS Style

Selepe, M.A.; Van Heerden, F.R. Application of the Suzuki-Miyaura Reaction in the Synthesis of Flavonoids. Molecules 2013, 18, 4739-4765.

AMA Style

Selepe MA, Van Heerden FR. Application of the Suzuki-Miyaura Reaction in the Synthesis of Flavonoids. Molecules. 2013; 18(4):4739-4765.

Chicago/Turabian Style

Selepe, Mamoalosi A.; Van Heerden, Fanie R. 2013. "Application of the Suzuki-Miyaura Reaction in the Synthesis of Flavonoids." Molecules 18, no. 4: 4739-4765.

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