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Molecules 2013, 18(1), 430-439; doi:10.3390/molecules18010430

Cross-Coupling Reaction with Lithium Methyltriolborate

1,* , 2, 2 and 1
1 Frontier Chemistry Center, Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan 2 Division of Chemical Process Engineering, Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan
* Author to whom correspondence should be addressed.
Received: 4 December 2012 / Revised: 21 December 2012 / Accepted: 27 December 2012 / Published: 28 December 2012
(This article belongs to the Special Issue Suzuki Reaction)
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We newly developed lithium methyltriolborate as an air-stable white solid that is convenient to handle. The good performance of this triolborate for metal-catalyzed bond-forming reactions was demonstrated in palladium-catalyzed cross-coupling reactions with haloarenes. Cross-coupling reaction of [MeB(OCH2)3CCH3]Li with aryl halides occurred in the presence of Pd(OAc)2/RuPhos complex in refluxing MeOH/H2O and the absence of bases.
Keywords: cross-coupling reaction; palladium catalyst; methyltrioolborate cross-coupling reaction; palladium catalyst; methyltrioolborate
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yamamoto, Y.; Ikizakura, K.; Ito, H.; Miyaura, N. Cross-Coupling Reaction with Lithium Methyltriolborate. Molecules 2013, 18, 430-439.

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