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Molecules 2013, 18(1), 430-439; doi:10.3390/molecules18010430

Cross-Coupling Reaction with Lithium Methyltriolborate

Frontier Chemistry Center, Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan
Division of Chemical Process Engineering, Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan
Author to whom correspondence should be addressed.
Received: 4 December 2012 / Revised: 21 December 2012 / Accepted: 27 December 2012 / Published: 28 December 2012
(This article belongs to the Special Issue Suzuki Reaction)
Download PDF [215 KB, 18 June 2014; original version 18 June 2014]


We newly developed lithium methyltriolborate as an air-stable white solid that is convenient to handle. The good performance of this triolborate for metal-catalyzed bond-forming reactions was demonstrated in palladium-catalyzed cross-coupling reactions with haloarenes. Cross-coupling reaction of [MeB(OCH2)3CCH3]Li with aryl halides occurred in the presence of Pd(OAc)2/RuPhos complex in refluxing MeOH/H2O and the absence of bases.
Keywords: cross-coupling reaction; palladium catalyst; methyltrioolborate cross-coupling reaction; palladium catalyst; methyltrioolborate
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yamamoto, Y.; Ikizakura, K.; Ito, H.; Miyaura, N. Cross-Coupling Reaction with Lithium Methyltriolborate. Molecules 2013, 18, 430-439.

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