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Cross-Coupling Reaction with Lithium Methyltriolborate
Frontier Chemistry Center, Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan
Division of Chemical Process Engineering, Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan
* Author to whom correspondence should be addressed.
Received: 4 December 2012; in revised form: 21 December 2012 / Accepted: 27 December 2012 / Published: 28 December 2012
Abstract: We newly developed lithium methyltriolborate as an air-stable white solid that is convenient to handle. The good performance of this triolborate for metal-catalyzed bond-forming reactions was demonstrated in palladium-catalyzed cross-coupling reactions with haloarenes. Cross-coupling reaction of [MeB(OCH2)3CCH3]Li with aryl halides occurred in the presence of Pd(OAc)2/RuPhos complex in refluxing MeOH/H2O and the absence of bases.
Keywords: cross-coupling reaction; palladium catalyst; methyltrioolborate
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Yamamoto, Y.; Ikizakura, K.; Ito, H.; Miyaura, N. Cross-Coupling Reaction with Lithium Methyltriolborate. Molecules 2013, 18, 430-439.
Yamamoto Y, Ikizakura K, Ito H, Miyaura N. Cross-Coupling Reaction with Lithium Methyltriolborate. Molecules. 2013; 18(1):430-439.
Yamamoto, Yasunori; Ikizakura, Kazuya; Ito, Hajime; Miyaura, Norio. 2013. "Cross-Coupling Reaction with Lithium Methyltriolborate." Molecules 18, no. 1: 430-439.