Special Issue "Cycloaddition Reactions in Organic Synthesis"

Guest Editor
Dr. Janis Louie
Department of Chemisty, the University of Utah, 315 S, 1400 East Salt Lake City, UT 84112, USA
Website: http://www.chem.utah.edu/faculty/louie/Home/
E-Mail:
Interests: Catalytic Activation of Heterocumulenes; Ni-Catalyzed Rearrangements: Rapid Entry to Carbocycles; CO2 Sequestering Agents

Dear Colleagues,

Cycloaddition reactions provide rapid access to natural and unnatural compounds of medicinal interest or intermediates useful for functional materials. In general, cycloadditions represent an efficient entry to ring systems and require readily available starting materials. In addition, many cycloaddition reactions tolerate a wide variety of functional groups. The focus of this special issue is to present papers that cover both fundamental and applied contributions in this field. Special attention will be paid to the development of new methodologies, mechanistic analysis of existing methodologies, and applications of cycloaddition reactions toward the synthesis of pharmalogically or industrially relevant materials.

Prof. Dr. Janis Louie
Guest Editor

Submission

• cycloaddition
• metal catalyzed organic transformations
• organocatalyzed transformations
• asymmetric catalysis
• mechanistic analysis
• medicinal chemistry

Manuscript ID: Molecules-cycladd-20091021-Kondo-jp
Type of Paper: Article
Title: Novel Rhodium-Catalyzed Linear Codimerization and Cycloaddition of Ketenes with Alkynes
Author: Teruyuki Kondo
Affiliation: Advanced Biomedical Engineering Research Unit, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan; E-Mail: teruyuki@scl.kyoto-u.ac.jp
Abstract: Novel rhodium-catalyzed linear codimerization of alkyl phenyl ketenes with alkynes to dienones, and novel synthesis of furans by unusual cycloaddition of diaryl ketenes with alkynes have been developed. These reactions proceeds smoothly with the same rhodium catalyst, RhCl(PPh₃)₃, and are highly dependent on the reactivity of starting ketenes.