Special Issue "Chemical Libraries"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 June 2012)
Dr. Olivier Sperandio
Research Associate at Inserm, Inserm UMR-S973/MTi. Université Paris Diderot, Bâtiment Lamarck - 5ème étage, salle 526, 35 Rue Hélène Brion – 75205 Paris Cedex 13, France
Interests: PPI (protein-protein interaction); i-PPI (inhibitors of protein-protein interactions); chemical space; drug-like compounds; chemical library screening; novel chemistry for PPI
Protein-protein interactions (PPI) are one of the next major class of therapeutic targets. There are approximately 650,000 PPI in humans for about 25,000 genes. The identification of drug-like modulators of these PPI represents a considerable challenge but conversely some unprecedent therapeutical and pharmacological benefits for human health. However, current techniques for experimental screening of commercial libraries, which usually allow the identification of new innovative compounds, have clearly demonstrated their limits on PPI. The main reason for these difficulties is the inadequacy of the chemical libraries used, which have been historically tailored for more conventional therapeutic targets. One of the major breakthroughs that may facilitate the identification of pharmacological compounds on PPI is a better understanding of the chemical space associated with them. The perspective of guiding the chemist and the biologist in their design of innovative chemistries for PPI and the creation of appropriate libraries is therefore of major importance.
This Special Issue on the design of chemical libraries for PPI represents an attractive forum to present innovative synthesis, rational design and cheminformatics analysis with the aim of facilitating the identification chemical probes on PPI for chemical biology and/or drug discovery projects. I strongly encourage authors to submit papers for this Special Issue, within the scope of Molecules. I hope that the topics covered will serve the chemists and biologists of the growing PPI community.
Dr. Olivier Sperandio
- PPI (protein-protein interaction)
- i-PPI (inhibitors of protein-protein interactions)
- chemical space
- drug-like compounds
- chemical library screening
- novel chemistry for PPI
Molecules 2011, 16(6), 5142-5148; doi:10.3390/molecules16065142
Received: 30 May 2011; in revised form: 15 June 2011 / Accepted: 15 June 2011 / Published: 21 June 2011| Download PDF Full-text (170 KB)
Molecules 2011, 16(8), 6349-6364; doi:10.3390/molecules16086349
Received: 30 June 2011; in revised form: 20 July 2011 / Accepted: 22 July 2011 / Published: 27 July 2011| Download PDF Full-text (710 KB) | Supplementary Files
Last update: 4 March 2014