Vitamin D and Bone Metabolism
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 40141
Special Issue Editors
Interests: osteoporosis; vitamin D; ageing; comorbidity; frailty; fracture risk; postmenopause
Interests: renal disease; glomerulonephritis; hemodialysis; renin angiotensin system
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Based on the recent literature, vitamin D has becoming a topic of interest in several areas of medicine. Vitamin D and related metabolites play a critical role in regulating skeletal homeostasis both indirectly and directly via the 1,25(OH)2D/VDR system. 1,25(OH)2D shows different roles in bone, acting either via endocrine or autocrine pathways, suggesting that vitamin D contributes lifelong to the maintenance of bone turn-over and bone strength. The local synthesis and activity of vitamin D within the bone microenvironment may contribute to the rationale for vitamin D supplementation in the condition of bone fragility. Vitamin D is also a major regulator of calcium and phosphorus metabolism with important implications in chronic kidney disease, and vitamin D deficiency has been strictly associated with rickets, osteomalacia, and osteoporosis. Other biological activities of vitamin D have recently been identified, including important aspects of cellular proliferation, differentiation, and the immune system. The interaction of vitamin D with other kidney hormones such as renin and erythropoietin is also interesting. Genetic and acquired diseases could impair the vitamin D system and thus impact bone and mineral metabolism. Due to the large amount of data on vitamin D, the main aim of this Special Issue will be to cover novel evidence focused on the contribution of vitamin D in bone metabolism and related outcomes. We therefore invite original contributions, reviews, and viewpoint manuscripts based on clinical and preclinical data on this proposed topic.
Prof. Antonino Catalano
Prof. Domenico Santoro
Guest Editors
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Keywords
- vitamin D
- calcium
- phosphorus
- FGF-23
- chronic kidney disease
- osteoporosis
- fractures
- osteoblasts
- osteoclasts
- osteocytes
- renal disease
- glomerulonephritis
- hemodialysis
- renin angiotensin system