Dear Colleagues,

We are pleased to announce a Special Issue of the journal Metabolites dedicated to approaches to investigate the metabolic adaptation of bacterial pathogens towards antibiotics.

The rapid development of bacterial resistance to antibiotics is among the most severe threats to human health. In the last 40 years, only two new classes of antibiotics have been introduced. Facing an increasing occurrence of pathogenic bacteria resistant to known antibiotics, the search for new antimicrobial compounds with possible new modes of action is an emerging field of research. Knowledge of the mechanisms with which bacteria cope with antimicrobial stress conditions is essential to understanding the modes of action and possible loopholes in which pathogens can escape the impact of antibiotics. Since naturally occurring molecules, in most cases, have many issues preventing their direct introduction to the clinic, the analysis of promising antimicrobial derivatives using metabolomics methods could pave the way to finding new antibiotics. This Special Issue aims to incorporate novel and review papers from a wide range of key topics in the field of antibiotics research.

Prof. Dr. Michael Lalk
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• antibiotics
• novel bioactive compounds
• modes of action
• cellular metabolic adaptation
• antibiotic resistance