Special Issue "Membrane Bioprocesses and Bioreactors"


A special issue of Membranes (ISSN 2077-0375).

Deadline for manuscript submissions: closed (30 June 2014)

Special Issue Editor

Guest Editor
Dr. José Sanchez-Marcano
Membranes European Institute, University of Montpellier 2, CC047 Place Eugène Bataillon, 34095 Montpellier-Cedex 5, France
Website: http://www.iemm.univ-montp2.fr/spip.php?article173&lang=fr
E-Mail: jose.sanchez@iemm.univ-montp2.fr
Phone: 33 467 14 91 19
Fax: 33 467 14 91 49
Interests: bio-catalytic and catalytic membrane reactors; modeling and simulation

Special Issue Information

Dear Colleagues,

Bioprocess or bioconversion is certainly the most significant industrial area where the concept of membrane reactors is actually being applied. There is a vast variety of possible applications, including the treatment of contaminated air and water streams or other less known applications, e.g., the microbial transformations or enzymatic reactions for the production of a broad spectrum of products such as liquid fuels (e.g., ethanol), plant metabolites, fine chemicals, aroma compounds, etc. These membrane bioprocesses are also important in pharmaceutical and medical industries, as they allow the production of complex molecules, e.g., hormones and monoclonal antibodies, or can be designed as artificial organs.

Membrane bioprocesses can be carried out in two different configurations. In the first, the coupling of the separation and the bioreaction in a single process is carried out by simply connecting two physically distinct units: the reactor and membrane separator. The second configuration allows the process intensification through the combination of both processes into a single unit: the membrane bioreactor. The modeling and simulation of such complex processes aims to determine the limiting parameters; coupling the mass transfers with biological kinetics is essential for the process optimization.

This Special Issue offers a perfect site to document the latest developments and innovations regarding membrane bioprocesses. Authors are therefore invited to submit their latest findings.

Dr. José Sanchez-Marcano
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • membrane bioprocess
  • membrane bioreactor
  • whole-cell membrane reactor
  • enzymatic membrane reactor
  • enzymatic membrane
  • artificial organs
  • modeling and simulation

Published Papers (3 papers)

by , ,  and
Membranes 2014, 4(3), 596-607; doi:10.3390/membranes4030596
Received: 29 June 2014; in revised form: 28 July 2014 / Accepted: 19 August 2014 / Published: 27 August 2014
Show/Hide Abstract | PDF Full-text (340 KB) | HTML Full-text | XML Full-text

by ,  and
Membranes 2014, 4(3), 372-387; doi:10.3390/membranes4030372
Received: 13 April 2014; in revised form: 26 May 2014 / Accepted: 1 July 2014 / Published: 15 July 2014
Show/Hide Abstract | PDF Full-text (681 KB) | HTML Full-text | XML Full-text
abstract graphic

by ,  and
Membranes 2014, 4(3), 319-332; doi:10.3390/membranes4030319
Received: 2 May 2014; in revised form: 24 June 2014 / Accepted: 30 June 2014 / Published: 8 July 2014
Show/Hide Abstract | PDF Full-text (291 KB) | HTML Full-text | XML Full-text

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Article
Title: Continuous Ethanol Production with a Membrane Bioreactor at High Acetic Acid Concentrations
s: Päivi Ylitervo 1,2,*, Carl Johan Franzén 2 and Mohammad J. Taherzadeh 1
s: 1 School of Engineering, University of Borås, 501 90 Borås, Sweden; E-Mails: paivi.ylitervo@hb.se (P.Y.), mohammad.taherzadeh@hb.se (M.J.T.)
Chemical and Biological Engineering - Industrial Biotechnology, Chalmers University of Technology, 412 96 Göteborg, Sweden; E-Mail: franzen@chalmers.se (C.J.F.)
The release of inhibitory concentrations of acetic acid from lignocellulosic raw materials during hydrolysis is one of the main concerns for ethanol production. It is the undissociated form of acetic acid which can enter the cell by diffusion through the plasma membrane and trigger several toxic effects such as uncoupling and lowered intracellular pH. Acetic acids effect on the ethanol production was studied in this investigated by adding medium containing from 2.5 up to 20.0 g L-1 acetic acid at pH 5.0 at a dilution rate of 0.5 h-1 to a continuous cultivation. The cultivations were performed at high yeast by retaining the yeast cells inside the reactor by a cross-flow membrane in a membrane bioreactor. The long term effect of acetic acid at different concentrations on the ethanol production revealed that the yeast was able to stably produce ethanol up to a concentration of 15.0 g L-1 acetic acid. However, the yeast continued to produce ethanol also at a concentration of 20 g L-1 acetic acid but at a reducing rate. The study thereby demonstrates the great potential of membrane bioreactor for improving the robustness of the ethanol production based on lignocellulosic raw materials.
acetic acid; membrane bioreactor; bioethanol; cell retention; yeast

Type of Paper: Article
Potentialities of a Membrane Reactor with Laccase Grafted Membranes for the Enzymatic Degradation of Phenolic Compounds in Water
V. Chea, D Paolucci, J Sanchez and MP Belleville*
IEM (Institut Européen des Membranes), UMR 5635 (CNRS-ENSCM-UM2), Université Montpellier 2, Place E. Bataillon, F-34095 Montpellier, France; E-Mail: Marie-Pierre.Belleville@univ-montp2.fr

Type of Paper: Review
Membrane Bioprocesses for Pharmaceutical Micropollutants Removal from Waters
M. De Cazes, R. Abejon, J. Sanchez and MP Belleville*
IEM (Institut Européen des Membranes), UMR 5635 (CNRS-ENSCM-UM2), Université Montpellier 2, Place E. Bataillon, F-34095 Montpellier, France; E-Mail: Marie-Pierre.Belleville@univ-montp2.fr

Last update: 14 March 2014

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