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Special Issue "Biocompatible Metals for Skeletal Fixation and Joint Replacement Devices"

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: 30 November 2017

Special Issue Editors

Guest Editor
Assoc. Prof. Dr. David Dean

Department of Plastic Surgery, Ohio State University, Columbus, OH 43210, USA
Website | E-Mail
Interests: craniofacial and bone; regenerative medicine; computer-aided implant design; geometric morphometrics; additive manufacturing (3D printing); tissue engineering; scaffold biomaterials; computer assisted surgery; implant
Guest Editor
Prof. Dr. Mohammad Elahinia

Dynamic and Smart Systems Laboratory, Mechanical Industrial and Manufacturing Engineering Department, The University of Toledo, OH 43606, USA
Website | E-Mail
Interests: additive manufacturing; 3D printing; shape memory alloys; materials engineering; finite element analysis; control systems engineering; product design and development; electrical engineering; design engineering; product development; manufacturing process mechanics; mechanical processes; machining; experimental analysis of behavior; design optimization; MR fluids; mechanical vibrations; medical devices; computer-aided engineering
Guest Editor
Dr. Jason Walker

Center for Innovation in Additive Manufacturing, Department of Mechanical & Industrial Engineering, Youngstown State University, Youngstown, OH 44555, USA
Website | E-Mail
Interests: additive manufacturing; 3D printing; aerospace engineering; shape memory alloys; tissue engineering; medical device design; materials engineering; machining; design optimization; computer-aided engineering; finite element analysis

Special Issue Information

Dear Colleagues,

Surgical Grade 5 Titanium (Ti-6Al-4V) is the standard of care material for metallic implants, used in hundreds of thousands of clinical implants annually. In addition to titanium, many other metals are gaining attention for their advantageous mechanical or resorbable properties. Both stress shielding of replaced or fixated bone, or stress concentrations in the device itself, are thought to be a common cause of short or long-term device failure. Less stiff metals such as nitinol (NiTi) are thought to be good candidates for fixation, joint replacement, and other devices because of their lower stiffness as well as their superelastic properties. Other metals, including magnesium (Mg) alloys that can resorb in a controlled and safe fashion, are also being studied as a means of providing skeletal fixation and to avoid long term stress shielding and stress concentrations. The metallurgy needed to form these alloys into biocompatible materials that can be fabricated (molten, solid ingots, or powders for 3D printing), especially if patient-specific designs are desired, present special challenges. This Special Issue of Materials, “Biocompatible Metals for Skeletal Fixation and Joint Replacement Devices”, promises to be a resource to the biomedical and biomaterial communities for some time to come.

Assoc. Prof. Dr. David Dean
Prof. Dr. Mohammad Elahinia
Dr. Jason Walker
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Stress shielding
  • Stress concentration
  • Skeletal fixation
  • Joint replacement
  • Ti-6Al-4V (Surgical Grade 5 Titanium)
  • NiTi
  • Beta titanium alloys
  • Magnesium
  • Shape memory
  • Superelasticity

Published Papers (1 paper)

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Research

Open AccessArticle Evaluation of the Healing Potential of Demineralized Dentin Matrix Fixed with Recombinant Human Bone Morphogenetic Protein-2 in Bone Grafts
Materials 2017, 10(9), 1049; doi:10.3390/ma10091049
Received: 16 August 2017 / Revised: 30 August 2017 / Accepted: 5 September 2017 / Published: 7 September 2017
PDF Full-text (7077 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
We aimed to evaluate the efficacy of demineralized dentin matrix (DDM) fixed with recombinant human bone morphogenetic protein-2 (rhBMP-2) through an experimental and a clinical study. Unilateral upper second and third premolars of eight beagles were extracted. A mucoperiosteal flap was elevated around
[...] Read more.
We aimed to evaluate the efficacy of demineralized dentin matrix (DDM) fixed with recombinant human bone morphogenetic protein-2 (rhBMP-2) through an experimental and a clinical study. Unilateral upper second and third premolars of eight beagles were extracted. A mucoperiosteal flap was elevated around the extraction socket, and a bone defect was made using a surgical drill. Each DDM was fixed with rhBMP-2, and autogenous bone was grafted at the bone defect area with a collagenous membrane. The beagles were euthanized at two, four, eight, and 12 weeks after receiving the bone graft. Block specimens involving grafted bone and surrounding natural bone were extracted. A total of 23 patients who received bone grafts using human DDM fixed with rhBMP-2 (AutoBT BMP) with implant placements (36 implants; maxilla: 14, mandible: 22) were selected. The implant stability, marginal bone loss, and clinical outcome were evaluated. Three trephine cores were harvested fourmonths after bone grafting, and histologic examination was performed. In the histological evaluation performed four weeks after the bone graft, autogenous bone showed 52% new bone formation and DDM fixed with rhBMP-2 showed 33% new bone formation. Twelve weeks after the bone graft, autogenous bone showed 75% new bone formation and DDM fixed with rhBMP-2 showed 48% new bone formation. In the clinical study, favorable osseointegration was obtained in 35 out of 36 implant sites (one case of osseointegration failure). In all cases, severe complications were not observed. Histomorphometrically, new bone formation was observed in 14.98% of the cases. The residual DDM particles were 6.22%. AutoBT BMP provides good osteoinductive and osteoconductive potential and clinical efficacy. Full article
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