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Materials 2017, 10(9), 1049; doi:10.3390/ma10091049

Evaluation of the Healing Potential of Demineralized Dentin Matrix Fixed with Recombinant Human Bone Morphogenetic Protein-2 in Bone Grafts

1
Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, 82 Gumi-ro 173, 173beon-gil, Bundang-gu, Seongnam 13620, Korea
2
Department of Dentistry & Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Korea
3
Department of Oral Histology-Developmental Biology, School of Dentistry, Seoul National University, Seoul 03080, Korea
4
R&D Institute, Korea Tooth Bank, Seoul 06101, Korea
5
Department of Science Education, College of Education, Dankook University, Yongin 16890, Korea
*
Author to whom correspondence should be addressed.
Received: 16 August 2017 / Revised: 30 August 2017 / Accepted: 5 September 2017 / Published: 7 September 2017
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Abstract

We aimed to evaluate the efficacy of demineralized dentin matrix (DDM) fixed with recombinant human bone morphogenetic protein-2 (rhBMP-2) through an experimental and a clinical study. Unilateral upper second and third premolars of eight beagles were extracted. A mucoperiosteal flap was elevated around the extraction socket, and a bone defect was made using a surgical drill. Each DDM was fixed with rhBMP-2, and autogenous bone was grafted at the bone defect area with a collagenous membrane. The beagles were euthanized at two, four, eight, and 12 weeks after receiving the bone graft. Block specimens involving grafted bone and surrounding natural bone were extracted. A total of 23 patients who received bone grafts using human DDM fixed with rhBMP-2 (AutoBT BMP) with implant placements (36 implants; maxilla: 14, mandible: 22) were selected. The implant stability, marginal bone loss, and clinical outcome were evaluated. Three trephine cores were harvested fourmonths after bone grafting, and histologic examination was performed. In the histological evaluation performed four weeks after the bone graft, autogenous bone showed 52% new bone formation and DDM fixed with rhBMP-2 showed 33% new bone formation. Twelve weeks after the bone graft, autogenous bone showed 75% new bone formation and DDM fixed with rhBMP-2 showed 48% new bone formation. In the clinical study, favorable osseointegration was obtained in 35 out of 36 implant sites (one case of osseointegration failure). In all cases, severe complications were not observed. Histomorphometrically, new bone formation was observed in 14.98% of the cases. The residual DDM particles were 6.22%. AutoBT BMP provides good osteoinductive and osteoconductive potential and clinical efficacy. View Full-Text
Keywords: rhBMP-2; demineralized dentin matrix rhBMP-2; demineralized dentin matrix
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MDPI and ACS Style

Kim, S.-Y.; Kim, Y.-K.; Park, Y.-H.; Park, J.-C.; Ku, J.-K.; Um, I.-W.; Kim, J.-Y. Evaluation of the Healing Potential of Demineralized Dentin Matrix Fixed with Recombinant Human Bone Morphogenetic Protein-2 in Bone Grafts. Materials 2017, 10, 1049.

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