Special Issue "Marine Antibiotics"
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (31 October 2012)
Prof. Dr. Sergey B. Zotchev
Department of Biotechnology, Norwegian University of Science and Technology, N-7491 Trondheim, Norway
Phone: +47 73 59 86 79
Fax: +47 73 59 12 83
Interests: streptomycetes; rare actinomycetes; antibiotics; secondary metabolite biosynthesis; engineering of biosynthetic pathways
Since the official discovery of the first antibiotic (penicillin), by Alexander Fleming in 1928, thousands of structurally diverse antibiotics have been reported from a variety of natural sources. Today, antibiotics continue to play the most important role in fighting various types of infections and saving millions of lives every year. However, rapid development of antibiotic resistance by bacterial and fungal pathogens, very limited supply of antiviral and antihelminthic antibiotics, and Big Pharma’s focusing mainly on chronic diseases and cancer represent a formidable challenge for anti-infective therapy of the future.
The absolute majority of currently used antibiotics have been isolated from terrestrial sources, and numerous attempts on terrestrial bioprospecting in the recent years mainly resulted in re-discovery of known antibiotics or their close analogues. Recent data strongly suggest that marine environment represents an untapped source for new biologically active molecules, in particular antibiotics. In this respect, marine bacteria and fungi seem to be the most prominent sources for antibiotic discovery due to their diversity and ability to grow rapidly and sustainably in bioreactors. Other sources, like sponges, corals and other marine animals, can also supply very interesting scaffolds for antibiotic discovery, which can be reproduced through chemical synthesis. Finally, metagenome libraries prepared from diverse marine samples and giving access to the genetic material from unculturable species may also supply new antibiotics.
This special issue of Marine Drugs is dedicated to marine antibiotics, and will be assembled to emphasize the importance of new antibiotic discovery from marine sources by various techniques and from a variety of organisms. I am very happy and honored to serve as a Guest Editor for this special issue, and would like to invite scientists to report their findings or review the recent literature on various aspects of marine antibiotics. I hope that this special issue will encourage other scientists to work on the important topic of the marine antibiotic discovery, and to report their findings in the future issues of Marine Drugs.
Prof. Dr. Sergey B. Zotchev
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed Open Access monthly journal published by MDPI.
- marine organisms
- chemical synthesis
- antibiotic resistance
- antibiotic modification
Article: Marine Myxobacteria as a Source of Antibiotics—Comparison of Physiology, Polyketide-Type Genes and Antibiotic Production of Three New Isolates of Enhygromyxa salina
Mar. Drugs 2010, 8(9), 2466-2479; doi:10.3390/md8092466
Received: 12 August 2010; in revised form: 25 August 2010 / Accepted: 1 September 2010 / Published: 3 September 2010| Download PDF Full-text (316 KB) | Download XML Full-text | Supplementary Files
Mar. Drugs 2010, 8(12), 2946-2960; doi:10.3390/md8122946
Received: 4 November 2010; in revised form: 1 December 2010 / Accepted: 9 December 2010 / Published: 13 December 2010| Download PDF Full-text (330 KB) | Download XML Full-text
Article: Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17
Mar. Drugs 2011, 9(3), 359-368; doi:10.3390/md9030359
Received: 7 February 2011; in revised form: 24 February 2011 / Accepted: 11 March 2011 / Published: 17 March 2011| Download PDF Full-text (584 KB) | Download XML Full-text
Article: Bactericidal Kinetics of Marine-Derived Napyradiomycins against Contemporary Methicillin-Resistant Staphylococcus aureus
Mar. Drugs 2011, 9(4), 680-689; doi:10.3390/md9040680
Received: 16 December 2010; in revised form: 15 February 2011 / Accepted: 13 April 2011 / Published: 21 April 2011| Download PDF Full-text (262 KB) | Download XML Full-text
Mar. Drugs 2012, 10(6), 1225-1243; doi:10.3390/md10061225
Received: 5 April 2012; in revised form: 21 May 2012 / Accepted: 28 May 2012 / Published: 4 June 2012| Download PDF Full-text (365 KB) | Download XML Full-text
Article: Evaluation of Pseudopteroxazole and Pseudopterosin Derivatives against Mycobacterium tuberculosis and Other Pathogens
Mar. Drugs 2012, 10(8), 1711-1728; doi:10.3390/md10081711
Received: 12 June 2012; in revised form: 25 July 2012 / Accepted: 1 August 2012 / Published: 15 August 2012| Download PDF Full-text (327 KB) | Download XML Full-text | Supplementary Files
Article: Gene Sequence Based Clustering Assists in Dereplication of Pseudoalteromonas luteoviolacea Strains with Identical Inhibitory Activity and Antibiotic Production
Mar. Drugs 2012, 10(8), 1729-1740; doi:10.3390/md10081729
Received: 28 June 2012; in revised form: 26 July 2012 / Accepted: 27 July 2012 / Published: 15 August 2012| Download PDF Full-text (384 KB) | Download XML Full-text
Article: Assessing the Effectiveness of Functional Genetic Screens for the Identification of Bioactive Metabolites
Mar. Drugs 2013, 11(1), 40-49; doi:10.3390/md11010040
Received: 18 October 2012; in revised form: 13 November 2012 / Accepted: 12 December 2012 / Published: 27 December 2012| Download PDF Full-text (473 KB) | Download XML Full-text
Article: Antibacterial Polyketides from the Marine Alga-Derived Endophitic Streptomyces sundarbansensis: A Study on Hydroxypyrone Tautomerism
Mar. Drugs 2013, 11(1), 124-135; doi:10.3390/md11010124
Received: 14 November 2012; in revised form: 4 December 2012 / Accepted: 25 December 2012 / Published: 10 January 2013| Download PDF Full-text (667 KB) | Download XML Full-text | Supplementary Files
Article: Iodinin (1,6-Dihydroxyphenazine 5,10-Dioxide) from Streptosporangium sp. Induces Apoptosis Selectively in Myeloid Leukemia Cell Lines and Patient Cells
Mar. Drugs 2013, 11(2), 332-349; doi:10.3390/md11020332
Received: 25 October 2012; in revised form: 21 December 2012 / Accepted: 4 January 2013 / Published: 30 January 2013| Download PDF Full-text (1041 KB) | Download XML Full-text
Article: Sponge-Derived Kocuria and Micrococcus spp. as Sources of the New Thiazolyl Peptide Antibiotic Kocurin
Mar. Drugs 2013, 11(4), 1071-1086; doi:10.3390/md11041071
Received: 19 December 2012; in revised form: 22 January 2013 / Accepted: 19 February 2013 / Published: 28 March 2013| Download PDF Full-text (360 KB) | Download XML Full-text | Supplementary Files
Last update: 10 October 2012