Mar. Drugs 2011, 9(3), 359-368; doi:10.3390/md9030359
Article

Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17

1 College of Marine Science, Zhejiang Ocean University, Zhoushan 316004, China 2 Marine Drugs Research Centre, China Pharmaceutical University, Nanjing 210018, China 3 Open Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China 4 School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
* Author to whom correspondence should be addressed.
Received: 7 February 2011; in revised form: 24 February 2011 / Accepted: 11 March 2011 / Published: 17 March 2011
(This article belongs to the Special Issue Marine Antibiotics)
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Abstract: Marine sponge Hymeniacidon sp. was collected from coastal waters of the East China Sea to isolate symbiotic microorganisms. The resulting sponge-associated actinomycete, Streptomyces carnosus strain AZS17, was cultivated in a 20 L volume of medium for production of bioactive secondary metabolites. Bioassay-guided isolation and purification by varied chromatographic methods yielded two new compounds of kijanimicin derivatives, AS7-2 and AS9-12. Their structures were elucidated by spectroscopy and comparison with literatures. Results showed these two compounds were structurally similar to the previously reported compounds lobophorin A and B, yet differed in specific bond forms, stereochemistry and optical activities. The two novel compounds were named lobophorin C and D. In vitro cytotoxicity investigation by MTT assay indicated their selective activities. Lobophorin C displayed potent cytotoxic activity against the human liver cancer cell line 7402, while lobophorin D showed significant inhibitory effect on human breast cancer cells MDA-MB 435.
Keywords: marine sponge; actinomycete; lobophorin C and D; cytotoxic activity

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MDPI and ACS Style

Wei, R.-B.; Xi, T.; Li, J.; Wang, P.; Li, F.-C.; Lin, Y.-C.; Qin, S. Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17. Mar. Drugs 2011, 9, 359-368.

AMA Style

Wei R-B, Xi T, Li J, Wang P, Li F-C, Lin Y-C, Qin S. Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17. Marine Drugs. 2011; 9(3):359-368.

Chicago/Turabian Style

Wei, Rong-Bian; Xi, Tao; Li, Jing; Wang, Ping; Li, Fu-Chao; Lin, Yong-Cheng; Qin, Song. 2011. "Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17." Mar. Drugs 9, no. 3: 359-368.

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