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Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17
College of Marine Science, Zhejiang Ocean University, Zhoushan 316004, China
Marine Drugs Research Centre, China Pharmaceutical University, Nanjing 210018, China
Open Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
* Author to whom correspondence should be addressed.
Received: 7 February 2011; in revised form: 24 February 2011 / Accepted: 11 March 2011 / Published: 17 March 2011
Abstract: Marine sponge Hymeniacidon sp. was collected from coastal waters of the East China Sea to isolate symbiotic microorganisms. The resulting sponge-associated actinomycete, Streptomyces carnosus strain AZS17, was cultivated in a 20 L volume of medium for production of bioactive secondary metabolites. Bioassay-guided isolation and purification by varied chromatographic methods yielded two new compounds of kijanimicin derivatives, AS7-2 and AS9-12. Their structures were elucidated by spectroscopy and comparison with literatures. Results showed these two compounds were structurally similar to the previously reported compounds lobophorin A and B, yet differed in specific bond forms, stereochemistry and optical activities. The two novel compounds were named lobophorin C and D. In vitro cytotoxicity investigation by MTT assay indicated their selective activities. Lobophorin C displayed potent cytotoxic activity against the human liver cancer cell line 7402, while lobophorin D showed significant inhibitory effect on human breast cancer cells MDA-MB 435.
Keywords: marine sponge; actinomycete; lobophorin C and D; cytotoxic activity
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MDPI and ACS Style
Wei, R.-B.; Xi, T.; Li, J.; Wang, P.; Li, F.-C.; Lin, Y.-C.; Qin, S. Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17. Mar. Drugs 2011, 9, 359-368.
Wei R-B, Xi T, Li J, Wang P, Li F-C, Lin Y-C, Qin S. Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17. Marine Drugs. 2011; 9(3):359-368.
Wei, Rong-Bian; Xi, Tao; Li, Jing; Wang, Ping; Li, Fu-Chao; Lin, Yong-Cheng; Qin, Song. 2011. "Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17." Mar. Drugs 9, no. 3: 359-368.