Cardiometabolic Disorders: From Pathophysiological Mechanism to Therapeutic Target
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 16931
Special Issue Editors
Interests: inflammatory bowel disease; diabetes mellitus; hypertension; heart failure; obstructive sleep apnea; nutrition; Mediterranean diet; orthorexia; nutritional habits
Special Issues, Collections and Topics in MDPI journals
2. Department of Pathophysiology, University of Split School of Medicine, 21000 Split, Croatia
3. Department of Health Studies, University of Split, 21000 Split, Croatia
Interests: interventional cardiology; acute coronary syndrome; myocardial infarction; thrombosis; percutaneous coronary intervention; atherosclerosis; acute heart failure; chronic heart failure; clinical trials
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiometabolic syndromes and disorders intersecting at the crossroads of cardiovascular disease and metabolic dysregulation are rapidly becoming a non-communicable pandemic of the 21st century. Majorly prevalent behaviors in modern societies, such as the lack of physical activity, a sedentary lifestyle, poor diet, smoking, alcohol use, and sleep deprivation, all act as independent risk factors able to trigger the onset of cardiometabolic disease. Such cardiometabolic derangements often coexist and encompass a spectrum of conditions such as insulin resistance, obesity, an impaired glucose tolerance, arterial hypertension, dyslipidemia, obstructive sleep apnea, and central adiposity. On the cellular level, these entities often exhibit complex pathophysiological pathways and interactions that entail a low-grade systemic inflammation, endothelial injury, sympathetic nervous system overactivity, alterations in the fatty acid metabolism, and cellular damage induced by reactive oxygen species. Therefore, the present Special Issue aims to feature the most comprehensive and up-to-date original articles and specialized reviews helping to understand the pathophysiological mechanisms and biological targets central to the development and progression of cardiometabolic disorders, as well as to illustrate how these cardiometabolic abnormalities can bring about adverse cardiovascular events such as myocardial infarction and stroke.
Dr. Josko Bozic
Dr. Josip Borovac
Guest Editors
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Keywords
- cardiometabolic syndrome
- cardiovascular disease
- coronary artery disease
- arterial hypertension
- glucose intolerance
- inflammation
- insulin resistance
- obstructive sleep apnea
- obesity
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