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Life
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New Advances in Endocrinology and Metabolic Diseases
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New Advances in Endocrinology and Metabolic Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 1690

Special Issue Editor

Dr. Chrysoula Boutari

E-Mail Website
Guest Editor
School of Medicine, Aristotle University of Thessalonik, Thessaloniki, Greece
Interests: hypertension; blood pressure; heart failure; atherosclerosis; cardiovascular medicine; insulin resistance; metabolism; metabolic diseases; lipid metabolism; glucose metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic diseases are currently on the rise and represent important risk factors for some of the most common and even fatal conditions, such as cardiovascular diseases (CVDs). Hypertension, dyslipidemia, diabetes mellitus, and especially obesity have reached pandemic dimensions. In addition, they are commonly accompanied by dire comorbidities, such as nonalcoholic fatty liver disease (NAFLD), CVDs, and obesity-associated malignancies. Their increasing prevalence represents a major public health burden.

This Special Issue is devoted to advances in the understanding of the mechanisms underlying metabolic diseases, the inter-relationship between them, and the progress in the prevention as well as treatment of these conditions. We welcome original research articles, reviews, systematic reviews, and case reports encompassing this area of interest.

Dr. Chrysoula Boutari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic syndrome
  • dyslipidemia
  • hypertension
  • obesity
  • diabetes mellitus
  • nonalcoholic fatty liver disease
  • cardiovascular diseases

Published Papers (1 paper)

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Research

16 pages, 4389 KiB  
Article
Profiling of Differentially Expressed MicroRNAs in Human Umbilical Vein Endothelial Cells Exposed to Hyperglycemia via RNA Sequencing
by Nur Syakirah Othman, Amilia Aminuddin, Shahidee Zainal Abidin, Saiful Effendi Syafruddin, Mohd Faizal Ahmad, Norfilza Mohd Mokhtar, Jaya Kumar, Adila A. Hamid and Azizah Ugusman
Life 2023, 13(6), 1296; https://doi.org/10.3390/life13061296 - 31 May 2023
Cited by 1 | Viewed by 1255
Abstract
Hyperglycemia is the hallmark of diabetes mellitus that results in oxidative stress, apoptosis, and diabetic vascular endothelial dysfunction. An increasing number of microRNAs (miRNAs) have been found to be involved in the pathogenesis of diabetic vascular complications. However, there is a limited number [...] Read more.
Hyperglycemia is the hallmark of diabetes mellitus that results in oxidative stress, apoptosis, and diabetic vascular endothelial dysfunction. An increasing number of microRNAs (miRNAs) have been found to be involved in the pathogenesis of diabetic vascular complications. However, there is a limited number of studies that characterize the miRNA profile of endothelial cells exposed to hyperglycemia. Therefore, this study aims to analyze the miRNA profile of human umbilical-vein endothelial cells (HUVECs) exposed to hyperglycemia. HUVECs were divided into two groups: the control (treated with 5.5 mM glucose) and hyperglycemia (treated with 33.3 mM glucose) groups. RNA sequencing identified 17 differentially expressed miRNAs between the groups (p < 0.05). Of these, 4 miRNAs were upregulated, and 13 miRNAs were downregulated. Two of the most differentially expressed miRNAs (novel miR-1133 and miR-1225) were successfully validated with stem-loop qPCR. Collectively, the findings show that there is a differential expression pattern of miRNAs in HUVEC following exposure to hyperglycemia. These 17 differentially expressed miRNAs are involved in regulating cellular functions and pathways related to oxidative stress and apoptosis that may contribute to diabetic vascular endothelial dysfunction. The findings provide new clues on the role of miRNAs in the development of diabetic vascular endothelial dysfunction, which could be useful in future targeted therapy. Full article
(This article belongs to the Special Issue New Advances in Endocrinology and Metabolic Diseases)
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